BRD3 anticorps

N° du produit ABIN4903072

Détail du produit anti-BRD3 anticorps

Antigène: BRD3 (Bromodomain Containing 3 (BRD3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BRD3 est non-conjugé

Application: Western Blotting (WB)

Attributs du produit: Nuclear protein in testis (NUT) is normally confined to the germ cells of the testis and ovary (1,2). NUT midline carcinoma (NMC) is a recently recognized cancer that is defined by the presence of chromosomal rearrangements involving the NUT gene on chromosome 15q14 (3). In most cases the chromosomal translocation occurs between NUT and BRD4 on chromosome 19, resulting in the formation of a BRD4-NUT fusion protein. In the remaining tumors, variant NUT rearrangements are present involving BRD3, a very close homolog of BRD4. BRD4-NUT and BRD3-NUT encode fusion proteins that appear to contribute to carcinogenesis by blocking epithelial cell differentiation. NMCs, which are aggressive and highly lethal carcinomas, are morphologically indistinguishable from other poorly differentiated carcinomas. Given the limited expression of endogenous NUT protein, this antibody can be used to detect NUT fusion proteins in tissues by immunohistochemistry and immunofluorescence (2).

Purification: Affinity purification

Immunogène: Recombinant protein of human BRD3.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: -20 °C

Stockage commentaire: Store at -20°C.

Détails sur BRD3

Antigène: BRD3 (Bromodomain Containing 3 (BRD3))

Autre désignation: BRD3 (BRD3 Produits)

Synonymes: anticorps ORFX, anticorps RING3L, anticorps 2410084F24Rik, anticorps AW060456, anticorps Fsrg2, anticorps RINGL3, anticorps brd3, anticorps fi36b10, anticorps wu:fa13h06, anticorps wu:fc01d09, anticorps wu:fc74a08, anticorps wu:fi04h10, anticorps wu:fi36b10, anticorps BRD3, anticorps ring3l, anticorps fa28f05, anticorps wu:fa28f05, anticorps wu:fc56a11, anticorps wu:fj66d12, anticorps zgc:77289, anticorps bromodomain containing 3, anticorps bromodomain containing 3a, anticorps bromodomain containing 3 S homeolog, anticorps bromodomain-containing protein 3, anticorps bromodomain containing 3b, anticorps BRD3, anticorps Brd3, anticorps brd3a, anticorps brd3.S, anticorps LOC100410652, anticorps LOC100354641, anticorps brd3b

ID gène: 8019

UniProt: Q15059

Pathways: Chromatin Binding