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IRF3 anticorps

IRF3 Reactivité: Humain Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN4904079
  • Antigène Voir toutes IRF3 Anticorps
    IRF3 (Interferon Regulatory Factor 3 (IRF3))
    Reactivité
    • 148
    • 93
    • 57
    • 31
    • 18
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 155
    • 16
    • 2
    Lapin
    Clonalité
    • 137
    • 36
    Polyclonal
    Conjugué
    • 94
    • 12
    • 9
    • 8
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp IRF3 est non-conjugé
    Application
    Veuillez nous consulter SVP
    Attributs du produit
    Interferon regulatory factors (IRFs) comprise a family of transcription factors that function within the Jak/Stat pathway to regulate interferon (IFN) and IFN-inducible gene expression in response to viral infection (1). IRFs play an important role in pathogen defense, autoimmunity, lymphocyte development, cell growth, and susceptibility to transformation. The IRF family includes nine members: IRF-1, IRF-2, ISGF3γ/p48, IRF-3, IRF-4 (Pip/LSIRF/ICSAT), IRF-5, IRF-6, IRF-7, and IRF-8/ICSBP. All IRF proteins share homology in their amino-terminal DNA-binding domains. IRF family members regulate transcription through interactions with proteins that share similar DNA-binding motifs, such as IFN-stimulated response elements (ISRE), IFN consensus sequences (ICS), and IFN regulatory elements (IRF-E) (2).IRF-3 can inhibit cell growth and plays a critical role in controlling the expression of genes in the innate immune response (1-4). In unstimulated cells, IRF-3 is present in the cytoplasm. Viral infection results in phosphorylation of IRF-3 and leads to its translocation to the nucleus where it activates promoters containing IRF-3-binding sites. Phosphorylation of IRF-3 occurs at a cluster of C-terminal Ser and Thr residues (between 385 and 405), leading to its association with the p300/CBP coactivator protein that promotes DNA binding and transcriptional activity (5). During infection, IRF-3 is likely activated through a pathway that includes activation of Toll-like receptors and a kinase complex that includes IKKε and TBK1 (6,7). IRF-3 is phosphorylated at Ser396 following viral infection, expression of viral nucleocapsid, and double-stranded RNA treatment. These events likely play a role in activation of IRF-3 (8).
    Purification
    Affinity purification
    Immunogène
    Recombinant protein of human IRF3.
    Isotype
    IgG
    Top Product
    Discover our top product IRF3 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000 , IHC 1:50-1:200 , IF 1:50-1:200 , IP 1:50-1:200 Ch, IP 1:20-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze/thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C.
  • Antigène
    IRF3 (Interferon Regulatory Factor 3 (IRF3))
    Autre désignation
    IRF3 (IRF3 Produits)
    Synonymes
    anticorps irf3, anticorps IRF3, anticorps C920001K05Rik, anticorps IRF-3, anticorps interferon regulatory factor 3, anticorps interferon regulatory factor 7, anticorps irf3, anticorps IRF3, anticorps irf-3, anticorps Irf3, anticorps IRF7
    ID gène
    3661
    UniProt
    Q14653
    Pathways
    Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
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