TAB2 anticorps
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- Antigène Voir toutes TAB2 Anticorps
- TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TAB2 est non-conjugé
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Application
- Western Blotting (WB)
- Attributs du produit
- The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
- Purification
- Affinity purification
- Immunogène
- Recombinant protein of human TAB2.
- Isotype
- IgG
- Top Product
- Discover our top product TAB2 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze/thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C.
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- Antigène
- TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))
- Autre désignation
- TAB2 (TAB2 Produits)
- Synonymes
- anticorps CHTD2, anticorps MAP3K7IP2, anticorps 1110030N06Rik, anticorps A530078N03Rik, anticorps Map3k7ip2, anticorps mKIAA0733, anticorps map3k7ip2, anticorps zgc:77446, anticorps TGF-beta activated kinase 1/MAP3K7 binding protein 2, anticorps TAB2, anticorps Tab2, anticorps tab2
- ID gène
- 23118
- UniProt
- Q9NYJ8
- Pathways
- TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway
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