BRCA1 anticorps (pSer988)

N° du produit ABIN540547

Détail du produit anti-BRCA1 anticorps

Antigène: BRCA1 (Breast Cancer 1 (BRCA1))

Épitope: pSer988

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BRCA1 est non-conjugé

Application: Immunofluorescence (IF)

Fonction: Rabbit polyclonal antibody raised against synthetic phosphopeptide of BRCA1.

Séquence: IKSpFV

Specificité: BRCA1 (phospho-Ser988) antibody detects endogenous levels of BRCA1 only when phosphorylated at serine 988.

Réactivité croisée: Humain

Attributs du produit: Antibody Reactive Against Synthetic Peptide.

Immunogène: Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S988 of human BRCA1.

Information d'application

Indications d'application: Immunofluorescence (1:100-1:200)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In PBS (without Mg²⁺ and Ca²⁺), 150 mM NaCl, pH 7.4 (50 % glycerol, 0.02 % sodium azide)

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C.
Aliquot to avoid repeated freezing and thawing.

Références pour anticorps anti-BRCA1 (ABIN540547)

Okada, Ouchi: "Cell cycle differences in DNA damage-induced BRCA1 phosphorylation affect its subcellular localization." dans: The Journal of biological chemistry, Vol. 278, Issue 3, pp. 2015-20, (2003) (PubMed).

Tutt, Ashworth: "The relationship between the roles of BRCA genes in DNA repair and cancer predisposition." dans: Trends in molecular medicine, Vol. 8, Issue 12, pp. 571-6, (2002) (PubMed).

Scully, Livingston: "In search of the tumour-suppressor functions of BRCA1 and BRCA2." dans: Nature, Vol. 408, Issue 6811, pp. 429-32, (2000) (PubMed).

Détails sur BRCA1

Antigène: BRCA1 (Breast Cancer 1 (BRCA1))

Autre désignation: BRCA1 / RNF53 (BRCA1 Produits)

Synonymes: anticorps BRCAI, anticorps BRCC1, anticorps BROVCA1, anticorps IRIS, anticorps PNCA4, anticorps PPP1R53, anticorps PSCP, anticorps RNF53, anticorps iris, anticorps pscp, anticorps brcai, anticorps brcc1, anticorps rnf53, anticorps brca1, anticorps BRCA1, anticorps LOC100224649, anticorps BRCA1, DNA repair associated, anticorps breast cancer 1, anticorps breast cancer 1, early onset, anticorps breast cancer 1 L homeolog, anticorps BRCA1, anticorps brca1, anticorps LOC755086, anticorps Brca1, anticorps brca1.L

ID gène: 672

Pathways: Cycle Cellulaire, Réparation de l'ADN, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus