FGF1 anticorps

N° du produit ABIN4951017

Détail du produit anti-FGF1 anticorps

Antigène: FGF1 (Fibroblast Growth Factor 1 (Acidic) (FGF1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FGF1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogène: Amino acids F16-D155 from the human protein were used as the immunogen for the FGF-1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the FGF-1 antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,IHC (FFPE): 0.5-1 μg/mL,ELISA: 0.1-0.5 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the FGF-1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur FGF1

Antigène: FGF1 (Fibroblast Growth Factor 1 (Acidic) (FGF1))

Autre désignation: FGF1 (FGF1 Produits)

Synonymes: anticorps AFGF, anticorps ECGF, anticorps ECGF-beta, anticorps ECGFA, anticorps ECGFB, anticorps FGF-1, anticorps FGF-alpha, anticorps FGFA, anticorps GLIO703, anticorps HBGF-1, anticorps HBGF1, anticorps Fgf1, anticorps FGF1, anticorps aFGF, anticorps ecgf, anticorps fgfa, anticorps ecgfa, anticorps ecgfb, anticorps fgf-1, anticorps hbgf1, anticorps glio703, anticorps ecgf-beta, anticorps fgf-alpha, anticorps Dffrx, anticorps Fam, anticorps Fgf-1, anticorps Fgfa, anticorps zgc:136885, anticorps LOC100221393, anticorps fgf1, anticorps zgc:73249, anticorps fibroblast growth factor 1, anticorps fibroblast growth factor 1 L homeolog, anticorps fibroblast growth factor 1b, anticorps fibroblast growth factor 1a, anticorps FGF1, anticorps fgf1.L, anticorps fgf1, anticorps Fgf1, anticorps fgf1b, anticorps LOC100221393, anticorps fgf1a

Sujet: Fibroblast growth factor 1 (acidic) plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. [UniProt]

UniProt: P05230

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway