FGF1 anticorps (Fibroblast Growth Factor 1 (Acidic))

Details for Product anti-FGF1 Antibody No. ABIN4951017
Antigène
  • AFGF
  • ECGF
  • ECGF-beta
  • ECGFA
  • ECGFB
  • FGF-1
  • FGF-alpha
  • FGFA
  • GLIO703
  • HBGF-1
  • HBGF1
  • Fgf1
  • FGF1
  • aFGF
  • ecgf
  • fgfa
  • ecgfa
  • ecgfb
  • fgf-1
  • hbgf1
  • glio703
  • ecgf-beta
  • fgf-alpha
  • Dffrx
  • Fam
  • Fgf-1
  • Fgfa
  • zgc:136885
  • LOC100221393
  • fibroblast growth factor 1
  • fibroblast growth factor 1 L homeolog
  • fibroblast growth factor 1b
  • FGF1
  • fgf1.L
  • fgf1
  • Fgf1
  • fgf1b
  • LOC100221393
Reactivité
Humain, Souris, Rat (Rattus)
154
90
61
15
10
6
5
4
4
4
4
3
3
2
1
1
1
Hôte
Lapin
194
35
Clonalité
Polyclonal
Conjugué
Cet anticorp FGF1 est non-conjugé
23
18
8
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
165
104
80
30
28
23
22
20
13
11
10
8
6
5
2
2
1
Options
Immunogène Amino acids F16-D155 from the human protein were used as the immunogen for the FGF-1 antibody.
Isotype IgG
Purification Antigen affinity
Plasmids, Primers & others Plasmids, Primers & others FGF1 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation FGF1 (FGF1 Antibody Extrait)
Sujet Fibroblast growth factor 1 (acidic) plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. [UniProt]
UniProt P05230
Pathways Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Indications d'application Optimal dilution of the FGF-1 antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,IHC (FFPE): 0.5-1 μg/mL,ELISA: 0.1-0.5 μg/mL
Restrictions For Research Use only
Buffer 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
Stock -20 °C
Stockage commentaire After reconstitution, the FGF-1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Images (Fournisseur)
Image no. 1 for anti-Fibroblast Growth Factor 1 (Acidic) (FGF1) antibody (ABIN4951017) Western blot testing of rat heart lysate with FGF-1 antibody. Predicted molecular wei...
Image no. 2 for anti-Fibroblast Growth Factor 1 (Acidic) (FGF1) antibody (ABIN4951017) IHC testing of FFPE human placenta with FGF-1 antibody. HIER: Boil the paraffin secti...
Image no. 3 for anti-Fibroblast Growth Factor 1 (Acidic) (FGF1) antibody (ABIN4951017) IHC testing of FFPE rat intestine with FGF-1 antibody. HIER: Boil the paraffin sectio...
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