FRZB anticorps (AA 176-325)

N° du produit ABIN4951095

Détail du produit anti-FRZB anticorps

Antigène: FRZB (Frizzled-Related Protein (FRZB))

Épitope: AA 176-325

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FRZB est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Antigen affinity

Immunogène: Amino acids 176-325 of human FRZB were used as the immunogen for the FRZB antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the FRZB antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,ELISA: 0.1-0.5 μg/mL (human protein tested), request BSA-free format for coating

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the FRZB antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur FRZB

Antigène: FRZB (Frizzled-Related Protein (FRZB))

Autre désignation: FRZB (FRZB Produits)

Synonymes: anticorps Frp, anticorps Sfrp3, anticorps frezzled, anticorps fritz, anticorps frzb-1, anticorps FRE, anticorps FRITZ, anticorps FRP-3, anticorps FRZB-1, anticorps FRZB-PEN, anticorps FRZB1, anticorps FZRB, anticorps OS1, anticorps SFRP3, anticorps SRFP3, anticorps hFIZ, anticorps Frzb-1, anticorps frizzled-related protein, anticorps Frzb, anticorps FRZB

Sujet: FRZB is also known as FRE or OS1. The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. FRZB is a Wnt-binding protein especially important in embryonic development. It is a competitor for the cell-surface G-protein receptor Frizzled. FRZB is localized in the extracellular plasma membrane. Unlike frizzled, frzb lacks the 7 transmembrane domains normally found in G-protein-coupled receptors. It is still considered a homolog of frizzled because it contains a Cysteine Rich Domain (CRD), and because of its intracellular C-terminus which is crucial for signaling.

UniProt: Q92765

Pathways: Signalisation WNT, Positive Regulation of fat Cell Differentiation