Optimal dilution of the GADD45A antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL
Restrictions
For Research Use only
Buffer
0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
Stock
-20 °C
Stockage commentaire
After reconstitution, the GADD45A antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Antigène
GADD45A
(Growth Arrest and DNA-Damage-Inducible, alpha (GADD45A))
anticorps MGC53491, anticorps zgc:91795, anticorps gadd45a, anticorps GADD45A, anticorps ddit1, anticorps gadd45, anticorps GADD45, anticorps AA545191, anticorps Ddit1, anticorps DDIT1, anticorps Gadd45, anticorps growth arrest and DNA damage inducible alpha L homeolog, anticorps growth arrest and DNA-damage-inducible, alpha, b, anticorps growth arrest and DNA damage inducible alpha, anticorps growth arrest and DNA damage-inducible protein 45, anticorps growth arrest and DNA-damage-inducible 45 alpha, anticorps growth arrest and DNA-damage-inducible, alpha, anticorps gadd45a.L, anticorps gadd45ab, anticorps GADD45A, anticorps gadd45a, anticorps GADD45, anticorps Gadd45a
Sujet
Growth arrest and DNA-damage-inducible protein GADD45 alpha (GADD45A) is a protein that in humans is encoded by the GADD45A gene. This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. It is located on 1p34-p12. Sequence analysis of human and hamster cDNA clones demonstrated that the gene has been highly conserved and encodes a novel 165-amino acid polypeptide. Northern blot analysis detected moderate expression of a 1.4-kb GADD45A transcript in heart, skeletal muscle, and kidney, with little or no expression in brain, placenta, lung, liver, and pancreas. In addition, Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation.