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HSD11B2 anticorps

HSD11B2 Reactivité: Humain, Rat, Souris WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN4951362
  • Antigène Voir toutes HSD11B2 Anticorps
    HSD11B2 (Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2))
    Reactivité
    • 45
    • 24
    • 24
    • 16
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Rat, Souris
    Hôte
    • 63
    • 4
    • 1
    Lapin
    Clonalité
    • 66
    • 2
    Polyclonal
    Conjugué
    • 29
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp HSD11B2 est non-conjugé
    Application
    • 54
    • 26
    • 19
    • 17
    • 17
    • 12
    • 7
    • 5
    • 4
    • 3
    • 3
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    Antigen affinity
    Immunogène
    Amino acids EKRKQLLLANLPQELLQAYGKDYIEHLHGQFLH of human HSD11B2 were used as the immunogen for the HSD11B2 antibody.
    Isotype
    IgG
    Top Product
    Discover our top product HSD11B2 Anticorps primaire
  • Indications d'application
    Optimal dilution of the HSD11B2 antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
    Restrictions
    For Research Use only
  • Buffer
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    Stock
    -20 °C
    Stockage commentaire
    After reconstitution, the HSD11B2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Antigène
    HSD11B2 (Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2))
    Autre désignation
    HSD11B2 (HSD11B2 Produits)
    Synonymes
    anticorps MGC81883, anticorps 11-HSD2, anticorps AME, anticorps AME1, anticorps HSD11K, anticorps HSD2, anticorps SDR9C3, anticorps 11HSD2, anticorps HSD11B2, anticorps hydroxysteroid (11-beta) dehydrogenase 2 L homeolog, anticorps hydroxysteroid 11-beta dehydrogenase 2, anticorps hsd11b2.L, anticorps HSD11B2, anticorps Hsd11b2
    Sujet
    Corticosteroid 11-β,-dehydrogenase isozyme 2, also known as 11-β,-hydroxysteroid dehydrogenase 2, is an enzyme that in humans is encoded by the HSD11B2 gene. There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.
    UniProt
    P80365
    Pathways
    Steroid Hormone Biosynthesis, Regulation of Systemic Arterial Blood Pressure by Hormones
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