KIF3A anticorps (AA 485-699)

N° du produit ABIN4951540

Détail du produit anti-KIF3A anticorps

Antigène: KIF3A (Kinesin Family Member 3A (KIF3A))

Épitope: AA 485-699

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KIF3A est non-conjugé

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogène: Amino acids 485-699 of human KIF3A were used as the immunogen for the KIF3A antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the KIF3A antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the KIF3A antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur KIF3A

Antigène: KIF3A (Kinesin Family Member 3A (KIF3A))

Autre désignation: KIF3A (KIF3A Produits)

Synonymes: anticorps FLA10, anticorps KLP-20, anticorps 111-11-71, anticorps 111-11-86, anticorps AW124694, anticorps Kif3, anticorps Kifl, anticorps Kns3, anticorps kinesin family member 3A, anticorps kinesin family member 3a, anticorps KIF3A, anticorps Kif3a

Sujet: Kinesin-like protein KIF3A is a protein that in humans is encoded by the KIF3A gene. KIF3A is one subunit of the heterotrimeric motor protein, kinesin-2, that was initially isolated from sea urchin egg/embryo cytosol using microtubule affinity purification. This motor consists of two kinesin-related subunits (called KIF3A and KIF3B or 3C in vertebrates) and an associated protein (KAP3), and it transports protein complexes, nucleic acids and organelles towards the plus ends of microtubule tracks within cells. Work done in a broad range of eukaryotic cells has revealed that heterotrimeric kinesin-2 is the primary motor protein driving the intra-flagellar transport of tubulins and other axonemal building blocks from the base of the ciliary/flagellar axoneme to their site of assembly at the distal tips. This process is required for cilium assembly/maintenance and cilium-based signalling which play key roles in various cell and developmental processes. For example, in vertebrate embryos, kinesin-2 function is required for cilia-dependent nodal flow and the development of left-right asymmetry.

UniProt: Q9Y496

Pathways: Signalisation Hedgehog