MAG anticorps

N° du produit ABIN4951814

Détail du produit anti-MAG anticorps

Antigène: MAG (Myelin Associated Glycoprotein (MAG))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAG est non-conjugé

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogène: Amino acids EPPELDLSYSHSDLGKRPTKDSYTLTEELAEYAEIRVK of human MAG/SIGLEC4A were used as the immunogen for the Myelin-associated glycoprotein antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Myelin-associated glycoprotein antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the Myelin-associated glycoprotein antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur MAG

Antigène: MAG (Myelin Associated Glycoprotein (MAG))

Autre désignation: MAG / Myelin-associated glycoprotein (MAG Produits)

Synonymes: anticorps GMA, anticorps S-MAG, anticorps SIGLEC-4A, anticorps SIGLEC4A, anticorps siglec-4, anticorps MAG, anticorps Gma, anticorps siglec-4a, anticorps myelin associated glycoprotein, anticorps myelin-associated glycoprotein, anticorps MAG, anticorps mag, anticorps Mag

Sujet: MAG (Myelin-associated glycoprotein), also known as SIGLEC4A, is a cell membrane glycoprotein that is a member of the SIGLEC family of proteins and is a functional ligand of the NOGO-66 receptor, NgR. It is thought to be involved in the process of myelination. Cleavage of GPI-linked proteins from axons protects growth cones from MAG-induced collapse, and dominant-negative NgR eliminates MAG inhibition of neurite outgrowth. MAG-resistant embryonic neurons were rendered MAG-sensitive by expression of NgR. MAG binds specifically to an NgR-expressing cell line in a GPI-dependent and sialic acid-independent manner. Experiments blocking NgR from interacting with MAG prevented inhibition of neurite outgrowth by MAG. In cultured human embryonic kidney (HEK) cells expressing the NOGO receptor, p75(NTR) was required for MAG-induced intracellular calcium elevation.

UniProt: P20916

Pathways: Neurotrophin Signaling Pathway