ABCB11 anticorps (AA 1038-1067)

N° du produit ABIN3030049

Détail du produit anti-ABCB11 anticorps

Antigène: ABCB11 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11))

Épitope: AA 1038-1067

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ABCB11 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Purification: Purified

Immunogène: A portion of amino acids 1038-1067 from the human protein was used as the immunogen for this ABCB11 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the ABCB11 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the ABCB11 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur ABCB11

Antigène: ABCB11 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11))

Autre désignation: ABCB11 (ABCB11 Produits)

Synonymes: anticorps ABCB11, anticorps Bsep, anticorps ABC16, anticorps BRIC2, anticorps BSEP, anticorps PFIC-2, anticorps PFIC2, anticorps PGY4, anticorps SPGP, anticorps Lith1, anticorps BSEP/SPGP, anticorps Spgp, anticorps ATP binding cassette subfamily B member 11, anticorps bile salt export pump, anticorps ATP-binding cassette, sub-family B (MDR/TAP), member 11, anticorps ABCB11, anticorps LOC100489744, anticorps LOC100565276, anticorps EDI_111220, anticorps EDI_272930, anticorps abcb11, anticorps Abcb11

Sujet: ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. It is expressed predominatly, if not exclusively, in the liver, where it is further localized to the canilicular microvilli and to subcanilicular vesicles fo the hepatocytes. Structurally, ABCB11 is a multifunctional polypeptide with two homologus halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis 2 (PFIC2). PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease.

UniProt: O95342