GABRG2 anticorps (Internal Region)

N° du produit ABIN498030

Détail du produit anti-GABRG2 anticorps

Antigène: GABRG2 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2))

Épitope: AA 400-410, Internal Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache)

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp GABRG2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Séquence: C-NNATHLQERD E

Specificité: This antibody is expected to recognize all reported isoforms: NP_944494.1, NP_000807.2, NP_944493.2.

Réactivité croisée (Details): Species reactivity (expected):Human, Bovine.
Species reactivity (tested):Mouse, Rat.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogène: Peptide with sequence from the internal region of the protein sequence according to NP_944494.1, NP_000807.2, NP_944493.2. Genename: GABRG2

Information d'application

Indications d'application: Peptide ELISA: Limit Dilution: 1/16000. Western blot: 1-3 μg/mL. Approx 50 kDa band observed in Mouse and Rat Brain lysates(calculated MW of 55.0 kDa according to Mouse NP_032099.1 and 54.0 kDa according to RatNP_899156.1).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur GABRG2

Antigène: GABRG2 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2))

Autre désignation: GABRG2 (GABRG2 Produits)

Synonymes: anticorps cae2, anticorps eca2, anticorps gabrg1, anticorps gefsp3, anticorps si:ch211-145n14.1, anticorps CAE2, anticorps ECA2, anticorps GEFSP3, anticorps GABAA-R, anticorps Gabrg-2, anticorps gamma2, anticorps gamma-aminobutyric acid type A receptor gamma2 subunit, anticorps gamma-aminobutyric acid (GABA) A receptor, gamma 2, anticorps gamma-aminobutyric acid type A receptor gamma 2 subunit, anticorps gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2, anticorps GABRG2, anticorps gabrg2, anticorps Gabrg2

Sujet: GABA A receptors are ligand-gated chloride channels that play a role as inhibitory neurotransmitters. They are known targets for certain classes of environmental and pharmaceutical compounds because a number of drugs interact with binding sites on GABA A. Some of these drugs include benzodiazepines, anticonvulsants, and anesthetics. GABA A Receptors are comprised of subunits and these are further classified into 3 major groups (alpha, beta, and gamma). The subunits determine the pharmacological characteristics. The binding of GABA to GABA A receptors results in the increase transportation of chlorine ions into the neuron. This influx results in signal transmission repression. Studies have shown that if cell to cell signaling goes unchecked due to a lack of GABA, a system "overload" can resulting in blackouts, rapid body contractions, seizures and epilepsy.Synonyms: GABA A Receptor subunit gamma-2, GABRG-2, Gamma-aminobutyric acid receptor subunit gamma-2

ID gène: 2566

NCBI Accession: NP_000807

UniProt: P18507