Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

SNAIL anticorps

SNAI1 Reactivité: Humain, Souris WB, IF, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN498268
  • Antigène Voir toutes SNAIL (SNAI1) Anticorps
    SNAIL (SNAI1)
    Reactivité
    • 95
    • 34
    • 19
    • 6
    • 3
    • 3
    • 3
    • 1
    Humain, Souris
    Hôte
    • 85
    • 10
    • 3
    • 2
    Lapin
    Clonalité
    • 90
    • 10
    Polyclonal
    Conjugué
    • 61
    • 7
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SNAIL est non-conjugé
    Application
    • 67
    • 45
    • 35
    • 18
    • 16
    • 14
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificité
    This antibody detects endogenous levels of SNAI 1 protein. (region surrounding Ala242)
    Réactivité croisée (Details)
    Species reactivity (expected):Mouse, Rat.
    Species reactivity (tested):Human.
    Purification
    Affinity Chromatography using epitope-specific immunogen.
    Top Product
    Discover our top product SNAI1 Anticorps primaire
  • Indications d'application
    Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200. Immunoflourescence: 1: 50 - 1: 200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.2, 0.05 % Sodium Azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Huang, Yu, Fu, Chen, Liu, Li, Xia, Zhang, Li: "EGFR inhibition prevents in vitro tumor growth of salivary adenoid cystic carcinoma." dans: BMC cell biology, Vol. 14, pp. 13, (2013) (PubMed).

    Yao, Li, Xiong, Li, Jiang, Chen: "A novel role of ribonuclease inhibitor in regulation of epithelial-to-mesenchymal transition and ILK signaling pathway in bladder cancer cells." dans: Cell and tissue research, Vol. 353, Issue 3, pp. 409-23, (2013) (PubMed).

    Pan, Xiong, Yao, Xin, Zhang, Chen: "Up-regulating ribonuclease inhibitor inhibited epithelial-to-mesenchymal transition and metastasis in murine melanoma cells." dans: The international journal of biochemistry & cell biology, Vol. 44, Issue 6, pp. 998-1008, (2012) (PubMed).

    Zou, Luo, Zeng, Dong, Wu, Liu: "Protein kinase CK2? is overexpressed in colorectal cancer and modulates cell proliferation and invasion via regulating EMT-related genes." dans: Journal of translational medicine, Vol. 9, pp. 97, (2011) (PubMed).

    Yang, Feng, Zhou, Liang, Mao, Deng, Yan, Sun, Du, Liu, Wang, Neckenig, Yang, Qu: "Aberrant expression of chemokine receptor CCR4 in human gastric cancer contributes to tumor-induced immunosuppression." dans: Cancer science, Vol. 102, Issue 7, pp. 1264-71, (2011) (PubMed).

    Feng, Di, Tao, Chang, Lu, Fan, Shan, Li, Yang: "PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development." dans: Molecular and cellular biology, Vol. 30, Issue 14, pp. 3711-21, (2010) (PubMed).

  • Antigène
    SNAIL (SNAI1)
    Autre désignation
    SNAI1 (SNAI1 Produits)
    Synonymes
    anticorps SLUGH2, anticorps SNA, anticorps SNAH, anticorps SNAIL, anticorps SNAIL1, anticorps dJ710H13.1, anticorps AI194338, anticorps Sna, anticorps Sna1, anticorps Snail, anticorps Snail1, anticorps SNAI1, anticorps BG:DS01845.1, anticorps CG3956, anticorps Dmel\\CG3956, anticorps Sco, anticorps br28, anticorps br29, anticorps l(2)35Db, anticorps l(2)br28, anticorps l(2)br29, anticorps l(3)br28, anticorps l35Db, anticorps sn, anticorps Xsnail, anticorps sna, anticorps snail1, anticorps xSna, anticorps Snai, anticorps sna2, anticorps snail2, anticorps cb643, anticorps sna-1, anticorps sna1, anticorps snai1, anticorps snail1a, anticorps zgc:109820, anticorps snail family transcriptional repressor 1, anticorps snail family zinc finger 1, anticorps snail homolog 1 (Drosophila), anticorps snail, anticorps zinc-finger transcription factor Snail, anticorps snail family zinc finger 1 S homeolog, anticorps protein escargot, anticorps transcription factor protein, anticorps snail zinc finger protein, anticorps snail family zinc finger 1b, anticorps snail family zinc finger 1a, anticorps SNAI1, anticorps Snai1, anticorps sna, anticorps snail, anticorps snai1.S, anticorps LOC410464, anticorps snai1b, anticorps snai1a
    Sujet
    The SNAIL family of developmental regulatory proteins is a group of widely conserved zinc-finger proteins that regulate transcription and include the mammalian proteins SLUG, SNAI 1, the human homolog of Drosophila SNAIL, and Smuc. SNAI 1 and SLUG are expressed in placenta and adult heart, liver and skeletal muscle. SNAI 1, and the corresponding mouse homolog Sn,a each contain three classic zinc fingers and one atypical zinc finger, while SLUG contains five zinc finger regions and a transcriptional repression domain at the amino terminus, which enables SLUG to act as a negative regulator of gene expression. SLUG is implicated in the generation and migration of neural crest cells in human embryos and also contributes to limb bud development. In addition, SLUG also constitutes a cellular anti-apoptotic transcription factor that effectively prevents apoptosis in murine pro-B cells deprived of IL-3. The SNAIL-related gene from murine skeletal muscle cells, Smuc, is highly expressed in skeletal muscle and thymus and can, likewise, repress gene transcription. Smuc preferentially associates with CAGGTG and CACCTG E-box motifs (CANNTG) on DNA and involves the five putative DNA-binding zinc finger domains at the C-terminal region of Smuc.Synonyms: Protein snail homolog 1, SNAH, Zinc finger protein SNAI1
    Poids moléculaire
    approx. 29 kDa
    ID gène
    6615
    NCBI Accession
    NP_005976
    UniProt
    O95863
    Pathways
    Negative Regulation of intrinsic apoptotic Signaling
Vous êtes ici:
Support technique