IRX1 anticorps

N° du produit ABIN498327

Détail du produit anti-IRX1 anticorps

Antigène: IRX1 (Iroquois Homeobox Protein 1 (IRX1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IRX1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of IRX1 protein. (region surrounding Asp231)

Réactivité croisée (Details): Species reactivity (expected):Mouse.
Species reactivity (tested):Human.

Purification: Affinity chromatography using epitope-specific immunogen

Pureté: > 95 % (by SDS-PAGE)

Information d'application

Indications d'application: Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200. Immunoflourescence: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur IRX1

Antigène: IRX1 (Iroquois Homeobox Protein 1 (IRX1))

Autre désignation: IRX1 / IRXA1 (IRX1 Produits)

Synonymes: anticorps IRX-5, anticorps IRXA1, anticorps IRX1, anticorps Xiro, anticorps Xiro1, anticorps iro1, anticorps irx-5, anticorps irx1, anticorps zgc:109702, anticorps zgc:136490, anticorps ziro1, anticorps ziro1a, anticorps Xiro-1, anticorps iro1-A, anticorps iro1-B, anticorps irx1-a, anticorps irx1-b, anticorps iroquois homeobox 1, anticorps Iroquois related homeobox 1 (Drosophila), anticorps iroquois homeobox 1a, anticorps iroquois homeobox 1 L homeolog, anticorps Putative iroquois-class homeodomain protein irx-1, anticorps iroquois homeobox 1 S homeolog, anticorps IRX1, anticorps Irx1, anticorps irx1, anticorps irx1a, anticorps irx1.L, anticorps irx-1, anticorps irx1.S

Sujet: The Iroquois homeobox gene family of transcription factors regulate aspects of embryonic development including anterior/posterior and dorsal/ventral axis patterning in the central nervous system. The Iroquois family are clustered on two loci, IRXA and IRXB, which map to chromosomes 8 and 13 in mice. The IRXA group includes Irx1, Irx2 and Irx4, the IRXB group is comprises Irx3, Irx5 and Irx6. Irx1 and Irx2 are both widely expressed during development in the lung epithelium and also in the ventricular septum. Irx1 and Irx2 also play a role in digit formation (E11.5-E14.5). The Irx gene family members are each expressed in a distinct pattern during mouse heart development. Specifically, Irx1 and Irx2 are expressed in the ventricular septum and Irx3 is expressed in the ventricular trabeculated myocardium. In addition, Irx4 is expressed in the linear heart tube and the AV canal, Irx5 is expressed in the endocardium lining the ventricular and atrial myocardium. Furthermore, the IRX4 gene may modulate cardiac development and function. Although the heart of Irx4- mice appears to develop normally, adult Irx4- mice exhibit cardiomyopathy, including cardiac hypertrophy and decreased contractility.Synonyms: Homeodomain protein IRXA1, IRX-1, Iroquois homeobox protein 1, Iroquois-class homeodomain protein IRX-1

Poids moléculaire: approx. 47 kDa

ID gène: 79192

NCBI Accession: NP_077313

UniProt: P78414

Pathways: Tube Formation