Translin anticorps

N° du produit ABIN498344

Détail du produit anti-Translin anticorps

Antigène: Translin (TSN)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Translin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This Antibody detects endogenous levels of Translin protein. (region surrounding Glu121)

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse, Rat.

Purification: Affinity Chromatography using epitope-specific immunogen

Information d'application

Indications d'application: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Translin

Antigène: Translin (TSN)

Abstract: TSN Produits

Synonymes: anticorps tsn, anticorps MGC52533, anticorps TSN, anticorps CG11761, anticorps Dmel\\CG11761, anticorps TB-RBP, anticorps BCLF-1, anticorps C3PO, anticorps RCHF1, anticorps REHF-1, anticorps TBRBP, anticorps TRSLN, anticorps 2610034C24Rik, anticorps AU040286, anticorps translin L homeolog, anticorps translin, anticorps haloacid dehalogenase, anticorps Translin, anticorps tsn.L, anticorps TSN, anticorps trsn, anticorps MMAH_RS03470, anticorps TAGG_RS05275, anticorps Igag_0962, anticorps MFER_RS03645, anticorps DESMU_RS01315, anticorps ARCVE_RS05265, anticorps MZHIL_RS01310, anticorps Tsn

Sujet: Translin, also designated testis brain RNA-binding protein (TB-RBP), is a single-stranded DNA- and RNA-binding protein that binds to the 3' UTR regions (Y and H elements) of stored mRNAs, which suppresses their in vitro translation. The human translin gene maps to chromosome 2q21.1 and encodes a 26 kDa protein that has been highly conserved throughout evolution. Translin forms a ring-shaped structure, which is responsible for DNA binding, and also contains a leucine zipper motif, which is thought to enable translin to form dimers. Translin exports specific mRNAs out of the nucleus, supported by its localization in both the nuclei and cytoplasm of neurons, and regulates their translation. Association with Trax (translin-associated factor X), inhibits the binding of translin to RNA, but enhances its binding to single stranded DNA sequences. Breakpoints in the TLS/FUS and CHOP loci contain consensus recognition motifs of translin, which associates with chromosomal translocations in liposarcomas.

Poids moléculaire: approx. 26 kDa

ID gène: 7247

NCBI Accession: NP_004613

UniProt: Q15631