KCNMB1 anticorps (Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 1)

Details for Product anti-KCNMB1 Antibody No. ABIN498565
Antigène
  • KCNMB1
  • BKbeta1
  • K(VCA)beta
  • SLO-BETA
  • hbeta1
  • hslo-beta
  • k(VCA)beta-1
  • slo-beta-1
  • BKBETA
  • potassium calcium-activated channel subfamily M regulatory beta subunit 1
  • potassium large conductance calcium-activated channel, subfamily M, beta member 1
  • KCNMB1
  • Kcnmb1
Reactivité
Humain, Souris, Rat (Rattus)
54
28
18
1
1
1
1
Hôte
Lapin
54
Clonalité
Polyclonal
Conjugué
Cet anticorp KCNMB1 est non-conjugé
5
4
4
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
31
21
13
3
2
2
1
1
1
Options
Specificité This antibody detects endogenous levels of MaxiKbeta protein. (region surrounding Lys119)
Réactivité croisée (Details) Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.
Purification Affinity chromatography
Pureté > 95 % by SDS-PAGE
Plasmids, Primers & others Plasmids, Primers & others KCNMB1 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation KCNMB1 (KCNMB1 Antibody Extrait)
Sujet The KCNMB1 gene, located on chromosome 5q34, contains four exons and encodes the 191 amino-acid protein MaxiKbeta subunit 1 (also designated calcium-activated potassium channel beta subunit, BK channel beta subunit, Slo-beta and KVCAbeta). MaxiKbeta subunit 1 consists of two putative transmembrane domains, an extracellular loop containing three consensus sequences for N-linked glycosylation and four cysteine residues that might form disulfide bridges. MaxiKbeta subunit 1, one of four subunits in the MaxiKbeta family, is expressed predominately in smooth muscle tissue but is also found in brain, liver and lymphatic tissues. MaxiKbeta subunit 1 associates with MaxiKalpha to form a calcium-activated potassium channel (also designated MaxiK and BK channel). MaxiKbeta subunit 1 increases the sensitivity of the MaxiKalpha to calcium and voltage. The MaxiKalpha/beta1 channel is the most sensitive of all Maxi channels to calcium. MaxiKbeta plays an important role in vasoregulation by controlling the sensitivity of MaxiK channels to calcium, which leads to the proper amount of arterial relaxation.Synonyms: BK channel beta-1, Calcium-activated potassium channel subunit beta-1, Charybdotoxin receptor subunit beta-1, K VCAbeta-1, Maxi K channel beta-1, Slo-beta-1, subfamily M beta-1
Poids moléculaire approx. 30 kDa
ID gène 3779
NCBI Accession NP_004128
UniProt Q16558
Indications d'application Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1,0 mg/mL
Buffer Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid repeated freezing and thawing.
Stock 4 °C/-20 °C
Stockage commentaire Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Images (Fournisseur)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 1 (KCNMB1) antibody (ABIN498565) Immunohistochemistry (IHC) analyzes of MaxiKbeta antibody in paraffin-embedded human ...
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