KCNMB1 anticorps

N° du produit ABIN498565

Détail du produit anti-KCNMB1 anticorps

Antigène: KCNMB1 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 1 (KCNMB1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KCNMB1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of MaxiKbeta protein. (region surrounding Lys119)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Pureté: > 95 % by SDS-PAGE

Information d'application

Indications d'application: Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur KCNMB1

Antigène: KCNMB1 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 1 (KCNMB1))

Autre désignation: KCNMB1 (KCNMB1 Produits)

Synonymes: anticorps KCNMB1, anticorps BKbeta1, anticorps K(VCA)beta, anticorps SLO-BETA, anticorps hbeta1, anticorps hslo-beta, anticorps k(VCA)beta-1, anticorps slo-beta-1, anticorps BKBETA, anticorps potassium calcium-activated channel subfamily M regulatory beta subunit 1, anticorps potassium large conductance calcium-activated channel, subfamily M, beta member 1, anticorps KCNMB1, anticorps Kcnmb1

Sujet: The KCNMB1 gene, located on chromosome 5q34, contains four exons and encodes the 191 amino-acid protein MaxiKbeta subunit 1 (also designated calcium-activated potassium channel beta subunit, BK channel beta subunit, Slo-beta and KVCAbeta). MaxiKbeta subunit 1 consists of two putative transmembrane domains, an extracellular loop containing three consensus sequences for N-linked glycosylation and four cysteine residues that might form disulfide bridges. MaxiKbeta subunit 1, one of four subunits in the MaxiKbeta family, is expressed predominately in smooth muscle tissue but is also found in brain, liver and lymphatic tissues. MaxiKbeta subunit 1 associates with MaxiKalpha to form a calcium-activated potassium channel (also designated MaxiK and BK channel). MaxiKbeta subunit 1 increases the sensitivity of the MaxiKalpha to calcium and voltage. The MaxiKalpha/beta1 channel is the most sensitive of all Maxi channels to calcium. MaxiKbeta plays an important role in vasoregulation by controlling the sensitivity of MaxiK channels to calcium, which leads to the proper amount of arterial relaxation.Synonyms: BK channel beta-1, Calcium-activated potassium channel subunit beta-1, Charybdotoxin receptor subunit beta-1, K VCAbeta-1, Maxi K channel beta-1, Slo-beta-1, subfamily M beta-1

Poids moléculaire: approx. 30 kDa

ID gène: 3779

NCBI Accession: NP_004128

UniProt: Q16558