SCN2A anticorps

N° du produit ABIN498571

Détail du produit anti-SCN2A anticorps

Antigène: SCN2A (Sodium Channel, Voltage-Gated, Type II, alpha Subunit (SCN2A))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SCN2A est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of Na+ CP type II-alpha protein. (region surrounding Lys1032)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen

Information d'application

Indications d'application: Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur SCN2A

Antigène: SCN2A (Sodium Channel, Voltage-Gated, Type II, alpha Subunit (SCN2A))

Autre désignation: SCN2A (SCN2A Produits)

Synonymes: anticorps SCN2A2, anticorps 6430408L10, anticorps A230052E19Rik, anticorps Nav1.2, anticorps Scn2a, anticorps NachII, anticorps RII/RIIA, anticorps RNSCPIIR, anticorps SCN, anticorps SCN2A, anticorps Scn2a2, anticorps ScpII, anticorps BFIC3, anticorps BFIS3, anticorps BFNIS, anticorps EIEE11, anticorps HBA, anticorps HBSCI, anticorps HBSCII, anticorps NAC2, anticorps Na(v)1.2, anticorps SCN2A1, anticorps sodium voltage-gated channel alpha subunit 2, anticorps sodium channel protein type 2 subunit alpha, anticorps sodium channel, voltage-gated, type II, alpha, anticorps sodium channel, voltage-gated, type II, alpha subunit, anticorps SCN2A, anticorps LOC100217927, anticorps LOC100389294, anticorps LOC100484218, anticorps Scn2a, anticorps LOC478773

Sujet: Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarize the cell. The three glycoproteins that comprise the voltagegated sodium channel proteins include a pore-forming alpha subunit, a noncovalently associated beta1 subunit and a disulfidelinked beta2 subunit. The two beta subunits regulate the level of channel expression, modulate gating and function as cell adhesion molecules for cellular aggregation and cytoskeleton interaction. The alpha subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type IIalpha subunits are more abundant along axons. The beta1 subunit of sodium channel type I is expressed in brain, skeletal and cardiac muscle. In the brain, beta1 and beta2 are highly expressed in Purkinje cells, and beta1 is also expressed in the pyramidal cells of the deep cerebellar nuclei. Impaired voltage-gated sodium channels lead to a number of diseases including myotonia.Synonyms: HBSC II, NAC2, SCN2A1, SCN2A2, Sodium channel protein brain II subunit alpha, Sodium channel protein type 2 subunit alpha, Sodium channel protein type II subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.2

ID gène: 6326

NCBI Accession: NP_001035232

UniProt: Q99250