PRSS3 anticorps

N° du produit ABIN498692

Détail du produit anti-PRSS3 anticorps

Antigène: PRSS3 (Protease, serine, 3 (PRSS3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRSS3 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody detects endogenous levels of Trypsin- 3 protein. (region surrounding Met166)

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography

Pureté: > 95 % by SDS-PAGE

Information d'application

Indications d'application: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur PRSS3

Antigène: PRSS3 (Protease, serine, 3 (PRSS3))

Autre désignation: Trypsin-3 / PRSS3 (PRSS3 Produits)

Synonymes: anticorps MTG, anticorps PRSS4, anticorps T9, anticorps TRY3, anticorps TRY4, anticorps Try3, anticorps Tb, anticorps prss3, anticorps protease, serine 3, anticorps trypsin-3, anticorps protease, serine, 3, anticorps trypsin III, anticorps protease, serine 3 L homeolog, anticorps PRSS3, anticorps CpipJ_CPIJ016105, anticorps Prss3, anticorps trp-iii, anticorps prss3.L

Sujet: The human pancreas secretes three different isoforms of the inactive trypsinogen into the small intestine, namely cationic trypsinogen, anionic trypsinogen (the two major isoforms) and mesotrypsinogen (a minor isoform). In the small intestine, each isoform is cleaved by Enterokinase into its active form, Trypsin-1, Trypsin-2 and Trypsin-3, respectively. All trypsins are members of the serine protease Trypsin family. The activated trypsins go on to activate other protease zymogens and play a role in the autoactivation of trypsinogens. This suggests an important role for trypsins in digestion. Mutations in the gene encoding Trypsin-1 that stimulate its activity are associated with autosomal dominant hereditary pancreatitis (HCP), also known as chronic pancreatitis (CP), a disease characterized by persistent, severe abdominal pain due to calcifications of the parenchyma, pancreatic stones, cysts and pancreatic head enlargement. Trypsin-3 is expressed in the brain in addition to the pancreas.Synonyms: Brain trypsinogen, Mesotrypsinogen, PRSS4, Serine protease 3, Serine protease 4, TRY3, TRY4, Trypsin III, Trypsin IV

Poids moléculaire: approx. 32 kDa

ID gène: 5646

NCBI Accession: NP_002762

UniProt: P35030