AATF anticorps

N° du produit ABIN499185

Détail du produit anti-AATF anticorps

Antigène: AATF (Apoptosis Antagonizing Transcription Factor (AATF))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AATF est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: AATF antibody was raised against a 12 amino acid peptide from near the carboxy terminus of human AATF.

Purification: Immunoaffinity purified IgG

Immunogène: Human AATF Peptide

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: AATF antibody can be used for the detection of AATF at 0.5 - 1 μg/mL. Humansmall intestine cell lysate can be used as positive control. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur AATF

Antigène: AATF (Apoptosis Antagonizing Transcription Factor (AATF))

Autre désignation: AATF (AATF Produits)

Synonymes: anticorps AATF, anticorps ded, anticorps che1, anticorps che-1, anticorps cb109, anticorps sb:cb109, anticorps wu:fc13d05, anticorps zgc:162071, anticorps CHE-1, anticorps CHE1, anticorps DED, anticorps 4933415H02Rik, anticorps 5830465M17Rik, anticorps Che-1, anticorps Trb, anticorps Ded, anticorps apoptosis antagonizing transcription factor, anticorps Apoptosis antagonizing transcription factor, anticorps apoptosis antagonizing transcription factor S homeolog, anticorps AATF, anticorps aatf, anticorps BFR2, anticorps NAEGRDRAFT_56916, anticorps Aatf, anticorps aatf.S

Sujet: AATF (apoptosis antagonizing transcription factor) was initially discovered as an interaction partner of ZIP kinase (ZIPK) (1), a member of death-associated protein (DAP) kinase family of pro-apoptotic serine/threonine kinases (2). AATF is a phosphoprotein containing an acidic region and a putative leucine zipper domain and nuclear localization signal, features which are typical of transcription factors. AATF inhibits the ZIPK-mediated pro-apoptotic pathway and may activate other anti-apoptotic pathways (3). Recently, it has also been shown to protect neural cells against oxidative damage induced by amyloid b-peptide and to inhibit aberrant production of the b-peptide by interacting with Par-4 (prostate apoptosis response-4), another pro-apoptotic leucine zipper protein that is associated with neuronal degeneration in Alzheimer's disease (AD) (4,5), suggesting that AATF may have potential therapeutic applications in both familial and sporadic forms of AD.Synonyms: Apoptosis-antagonizing transcription factor, CHE-1, CHE1, DED, HSPC277, Rb-binding protein Che-1

ID gène: 26574

NCBI Accession: NP_036270

UniProt: Q9NY61

Pathways: Neurotrophin Signaling Pathway, SARS-CoV-2 Protein Interactome