C1QTNF2
Reactivité: Humain, Souris
WB, ELISA
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
ELISA. Western Blot: CTRP2 polyclonal antibody can be used for the detection of CTRP2 at 2 - 4 μg/mL. These proteins are often highly modified post-translationally and migrate inSDS-PAGE at positions other than their predicted size. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Buffer
PBS containing 0.02 % sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C
Stockage commentaire
Store the antibody undiluted at 2-8 °C.
Antigène
C1QTNF2
(C1q and Tumor Necrosis Factor Related Protein 2 (C1QTNF2))
anticorps C1QTNF2, anticorps fe50b04, anticorps wu:fe50b04, anticorps CTRP2, anticorps zacrp2, anticorps 1810033K05Rik, anticorps Ctrp2, anticorps RGD1561041, anticorps C1q and tumor necrosis factor related protein 2, anticorps C1q and TNF related 2, anticorps C1QTNF2, anticorps c1qtnf2, anticorps C1qtnf2
Sujet
Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines (reviewed in 1). One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-related proteins (CTRPs) 1-7 (2). Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues (3). These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene (4). Of the CTRPs, CTRP2 is most similar structurally and functionally to adiponectin. Recombinant CTRP2 rapidly activated AMPK and MAPK in cultured C2C12 cells, leading to increased glycogen accumulation and fatty acid oxidation (3).Synonyms: CTRP2, Complement C1q tumor necrosis factor-related protein 2