Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1) (Middle Region) anticorps

N° du produit ABIN500304

Détail du produit

Antigène: Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1)

Épitope: Middle Region

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody detects NADE / BEX3.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse

Purification: Ion exchange chromatography

Immunogène: NADE antibody was raised against a peptide corresponding to 14 amino acids near the middle of human NADE.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 0.5 to 2 μg/mL. Despite its predicted molecular weight, NADE migrates at approx. 23 kDa in SDS-PAGE. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détail du antigène

Antigène: Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1)

Autre désignation: NADE / BEX3 (NGFRAP1 Produits)

Sujet: The p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis receptor superfamily and can mediate cell death and cell survival in response to nerve growth factor (NGF) (1 for review). The p75NTR-associated cell death executor (NADE) mediates apoptosis by interacting with the cell death domain of p75NTR following the binding of NGF by p75NTR (2). Recent studies have shown that NADE also interacts with second mitochondria-derived activator of caspase (Smac). Co-expression of NADE and Smac promotes TRAIL-induced apoptosis and inhibits XIAP-mediated Smac ubiquitization. It has been suggested that it is this interaction between NADE and Smac that allows apoptosis to proceed (5). Finally, although initially discovered as an mRNA expressed in ovarian granulosa cells (3), NADE has been suggested to play a role in the neuronal death seen in epileptic brain damage (4).Synonyms: Brain-expressed X-linked protein 3, DXS6984E, NGFRAP1, p75NTR-associated cell death executor

ID gène: 27018

NCBI Accession: NP_996798

UniProt: Q00994

Pathways: Neurotrophin Signaling Pathway, Positive Regulation of Endopeptidase Activity