NPC1 anticorps (C-Term)

N° du produit ABIN500383

Détail du produit anti-NPC1 anticorps

Antigène: NPC1 (Niemann-Pick Disease, Type C1 (NPC1))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NPC1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody detects NPC1. It will not cross-react to NPC2, another gene whose defects also result in Niemann-Pick type C disease.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Peptide affinity chromatography

Immunogène: NPC1 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human NPC1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 1 - 2 μg/mL. Imunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur NPC1

Antigène: NPC1 (Niemann-Pick Disease, Type C1 (NPC1))

Autre désignation: NPC1 (NPC1 Produits)

Synonymes: anticorps NPC, anticorps 9130221N23Rik, anticorps Gm243, anticorps Cdig2, anticorps im:7149020, anticorps wu:fb53a12, anticorps wu:fc29a12, anticorps A430089E03Rik, anticorps C85354, anticorps D18Ertd139e, anticorps D18Ertd723e, anticorps lcsd, anticorps nmf164, anticorps spm, anticorps NPC intracellular cholesterol transporter 1, anticorps NPC1 like intracellular cholesterol transporter 1, anticorps Niemann-Pick disease, type C1, anticorps Niemann-Pick C1 protein, anticorps NPC1, anticorps Npc1l1, anticorps Npc1, anticorps npc1, anticorps LOC579887

Sujet: Mutations in the Niemann-Pick disease type C1 (NPC1) gene result in a fatal progressive neurodegenerative disorder characterized by an abnormal sequestration of lipids including cholesterol and glycosphingolipids. The NPC1 protein is a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. NPC1 transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. NPC1, in addition to FTO, MC4R, and PTER has recently been shown to be a new risk loci for early-onset and morbid adult obesity in European populations.Synonyms: Niemann-Pick C1 protein

ID gène: 4864

NCBI Accession: NP_000262

UniProt: O15118