CRADD anticorps (C-Term)

N° du produit ABIN500563

Détail du produit anti-CRADD anticorps

Antigène: CRADD (CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CRADD est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody detects RAIDD at C-term.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Peptide affinity chromatography

Immunogène: RAIDD antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human RAIDD.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 1: 500 - 1: 1000, a 22 kDa band should be detected. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur CRADD

Antigène: CRADD (CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD))

Autre désignation: RAIDD (CRADD Produits)

Synonymes: anticorps cradd, anticorps MGC89035, anticorps zgc:101717, anticorps CRADD, anticorps DKFZp468A2219, anticorps LOC100226369, anticorps raidd, anticorps MGC78788, anticorps MRT34, anticorps RAIDD, anticorps CASP2 and RIPK1 domain containing adaptor with death domain, anticorps CASP2 and RIPK1 domain containing adaptor with death, gene 1, anticorps CASP2 and RIPK1 domain containing adaptor with death, gene 2 S homeolog, anticorps CRADD, anticorps cradd.1, anticorps cradd, anticorps cradd.2.S, anticorps Cradd

Sujet: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain (DD)-containing receptors, TNFR1 and Fas. The death signals are transduced by a group of DD-containing adapter molecules. A novel cell death adapter was recently identified by two independent groups and designated RAIDD (RIP-associated ICH-1/CED-3-homologous protein with DD) and CRADD (caspase and RIP adapter with DD)1,RAIDD contains a DD and a CARD (for caspase recruitment domain) which interact with RIP and caspase, respectively, to transduce death signals. RAIDD is constitutively expressed in many tissues and mediates apoptosis caused by Fas and TNFR-1.Synonyms: CRADD, Caspase and RIP adapter with death domain, Death domain-containing protein CRADD, RIP-associated protein with a death domain

ID gène: 8738

UniProt: P78560

Pathways: Apoptose, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity