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UNC93B1 anticorps (N-Term)

UNC93B1 Reactivité: Humain, Souris, Rat WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN501104
  • Antigène Voir toutes UNC93B1 Anticorps
    UNC93B1 (Unc-93 Homolog B1 (UNC93B1))
    Épitope
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 16
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Humain, Souris, Rat
    Hôte
    • 15
    • 1
    Lapin
    Clonalité
    • 16
    Polyclonal
    Conjugué
    • 9
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp UNC93B1 est non-conjugé
    Application
    • 8
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody detects Unc93b. The antibody will not cross-react with Unc93a.
    Réactivité croisée (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Affinity chromatography
    Immunogène
    Unc93b antibody was raised against a 19 amino acid peptide from near the amino terminus of human Unc93b.
    Isotype
    IgG
    Top Product
    Discover our top product UNC93B1 Anticorps primaire
  • Indications d'application
    ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Antigène
    UNC93B1 (Unc-93 Homolog B1 (UNC93B1))
    Autre désignation
    UNC93B1 (UNC93B1 Produits)
    Synonymes
    anticorps UNC93, anticorps IIAE1, anticorps UNC93B, anticorps Unc-93B1, anticorps Unc93b, anticorps unc-93 homolog B1, TLR signaling regulator, anticorps unc-93 homolog B1 (C. elegans), anticorps UNC93B1, anticorps Unc93b1
    Sujet
    The endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C. elegans Unc93 gene, was initially identified by a forward genetic screen using N-ethyl-N-nitrosourea where a histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7 and 9 signaling. Unlike Unc93a, another homolog of the C. elegans Unc93 gene whose function is unknown, Unc93b specifically interacts with TLR3, 7 and 9, the histidine-to-arginine point mutation used to identify Unc93b abolishes this interaction. Mice carrying this point mutation are highly susceptible to infection with a number of viruses, indicating that Unc93b plays an important role in innate immunity. Multiple isoforms of Unc93a are known to exist.Synonyms: Protein unc-93 homolog B1, UNC-93B, UNC93
    ID gène
    81622
    NCBI Accession
    NP_112192
    Pathways
    Signalisation TLR, Activation of Innate immune Response, Toll-Like Receptors Cascades
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