GBL anticorps (AA 100-320)
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- Antigène Voir toutes GBL Anticorps
- GBL (G protein beta subunit-like (GBL))
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Épitope
- AA 100-320
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp GBL est non-conjugé
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Application
- Western Blotting (WB)
- Purification
- Protein A Chromatography
- Immunogène
- A partial length recombinant LST8/GBL protein (amino acids 100-320) was used as the immunogen for this antibody.
- Isotype
- IgG
- Top Product
- Discover our top product GBL Anticorps primaire
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- Indications d'application
- WB: 1-3 μg/mL.
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- PBS containing 0.05 % BSA, PH 7.4
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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- Antigène
- GBL (G protein beta subunit-like (GBL))
- Autre désignation
- LST8/GBL (GBL Produits)
- Synonymes
- anticorps gbl, anticorps lts8, anticorps GBL, anticorps GbetaL, anticorps LST8, anticorps POP3, anticorps WAT1, anticorps 0610033N12Rik, anticorps AA409454, anticorps AI505104, anticorps AI851821, anticorps Gbl, anticorps fi37e04, anticorps wu:fi37e04, anticorps zgc:55455, anticorps zgc:85668, anticorps MTOR associated protein, LST8 homolog L homeolog, anticorps MTOR associated protein, LST8 homolog, anticorps MTOR associated protein, LST8 homolog (S. cerevisiae), anticorps mlst8.L, anticorps MLST8, anticorps Mlst8, anticorps mlst8
- Sujet
- MLST8 or GbL (G protein beta protein subunit-like) is a subunit of mTORC1 and mTORC2 which regulates cell growth and survival. Both mTORC1 and 2 are activated in response to growth factors or amino acids but mTORC2 is most likely insensitive towards nutrients. Within mTORC1, LST8 interacts directly with mTOR and helps to enhance its kinase activity. mTORC1 phosphorylates EIF4EBP1 and thereby releasing it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. LST8/GBL more or less ubiquitously expressed with highest levels in skeletal muscle, heart and kidney.
- Poids moléculaire
- 38 kDa
- ID gène
- 64223
- UniProt
- Q9BVC4
- Pathways
- Signalisation PI3K-Akt, Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, Autophagy, CXCR4-mediated Signaling Events, BCR Signaling, L'effet Warburg
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