Vangl1 anticorps (AA 148-400)

N° du produit ABIN5027627

Détail du produit anti-Vangl1 anticorps

Antigène: Vangl1 (Vang-Like 1 (Vangl1))

Épitope: AA 148-400

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Vangl1 est non-conjugé

Application: Western Blotting (WB)

Purification: Protein A Chromatography

Immunogène: A partial length recombinant Vang like-1 protein (amino acids 148-400) was used as the immunogen for this antibody.

Isotype: IgG

Information d'application

Indications d'application: WB: 2-4 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur Vangl1

Antigène: Vangl1 (Vang-Like 1 (Vangl1))

Autre désignation: Vang like-1 (Vangl1 Produits)

Synonymes: anticorps stb2, anticorps Kitenin, anticorps Lpp2, anticorps Stb2, anticorps Stbm, anticorps KITENIN, anticorps LPP2, anticorps STB2, anticorps STBM2, anticorps VANGL planar cell polarity protein 1, anticorps vang-like 1 (van gogh, Drosophila), anticorps Vangl1, anticorps vangl1, anticorps VANGL1

Sujet: Vangl1 (VANGL planar cell polarity protein 1) is an integral membrane protein that belongs to the tetraspanin family having four transmembrane domains. Tetraspanins form large multimolecular complexes on the cell membrane and are involved in cellular signaling, membrane formation, and migration. Vangl1 is expressed at the plasma membrane of different tissues and play a critical role in establishing planar cell polarity (PCP) in epithelial cells and are required for convergent extension (CE) movements during embryogenesis. It is a highly conserved and have evolved from a single ancestral protein Strabismus/Van Gogh found in Drosophila. Mutations in the vangl1 gene cause NTDs (neural tube defects). Ser/Thr phosphorylation of Vangl1 serves as an effector mediating the ITF healing response of the intestinal mucosa. In colon carcinoma cell lines, Vangl1 interacts with KAI1 (CD82) tumor metastasis suppressor. Vangl1 overexpression increases motility and metastasis, whereas its inhibition decreases motility and metastasis of colon cancer confirming migratory phenotype for Vangl1 in colonic epithelial cells.

Poids moléculaire: 62 kDa

ID gène: 81839

UniProt: Q8TAA9

Pathways: Signalisation WNT