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SQSTM1 anticorps (AA 335-345) (Alkaline Phosphatase (AP))

SQSTM1 Reactivité: Humain WB Hôte: Lapin Polyclonal Alkaline Phosphatase (AP)
N° du produit ABIN5066110
  • Antigène Voir toutes SQSTM1 Anticorps
    SQSTM1 (Sequestosome 1 (SQSTM1))
    Épitope
    • 19
    • 17
    • 15
    • 13
    • 11
    • 10
    • 8
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 335-345
    Reactivité
    • 171
    • 64
    • 61
    • 18
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 145
    • 24
    • 1
    • 1
    Lapin
    Clonalité
    • 144
    • 27
    Polyclonal
    Conjugué
    • 78
    • 13
    • 12
    • 8
    • 8
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SQSTM1 est conjugé à/à la Alkaline Phosphatase (AP)
    Application
    • 121
    • 58
    • 50
    • 40
    • 25
    • 23
    • 18
    • 16
    • 14
    • 13
    • 10
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Specificité
    Ubiquitously expressed.,Detects ~60 kDa. Band at 40 kDa is isoform 2.
     Réactivité croisée
    Humain, Souris
    Purification
    Peptide Affinity Purified
    Immunogène
    Synthetic peptide from the C-terminal of Human SQSTM1 (aa. 335-345)
    Isotype
    IgG
    Top Product
    Discover our top product SQSTM1 Anticorps primaire
  • Indications d'application
    • WB (1:1000)
    • optimal dilutions for assays should be determined by the user.
    Commentaires

    A 1:1000 dilution of ABIN5066110 was sufficient for detection of SQSTM1 in 15 μg of Human HeLa Cell Lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Conjugated antibodies should be stored at 4°C
  • Antigène
    SQSTM1 (Sequestosome 1 (SQSTM1))
    Autre désignation
    SQSTM1 (SQSTM1 Produits)
    Synonymes
    anticorps SQSTM1, anticorps sqstm1, anticorps MGC79491, anticorps A170, anticorps OSIL, anticorps PDB3, anticorps ZIP3, anticorps p60, anticorps p62, anticorps p62B, anticorps OSF-6, anticorps Osi, anticorps STAP, anticorps ZIP, anticorps sb:cb621, anticorps zgc:85784, anticorps sequestosome 1, anticorps sequestosome 1 L homeolog, anticorps SQSTM1, anticorps sqstm1, anticorps Sqstm1, anticorps sqstm1.L
    Sujet
    SQSTM1 or Sequestome 1 (p62) is a ubiquitin binding protein that interacts with ubiqutin, providing a scaffold for several signaling proteins and triggering degradation of proteins throught the proteasome or lysossome. This gene regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Mutations in this gene result in sporadic and familial Paget disease of bone. SQSTM1 also binds autophagosomal membrane protein LC3/ATG8.
    ID gène
    8878
    NCBI Accession
    NP_001135770
    UniProt
    Q13501
    Pathways
    Signalisation NF-kappaB, Neurotrophin Signaling Pathway, Autophagy
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