SQSTM1 anticorps (AA 335-345) (Alkaline Phosphatase (AP))
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- Antigène Voir toutes SQSTM1 Anticorps
- SQSTM1 (Sequestosome 1 (SQSTM1))
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Épitope
- AA 335-345
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SQSTM1 est conjugé à/à la Alkaline Phosphatase (AP)
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Application
- Western Blotting (WB)
- Specificité
- Ubiquitously expressed.,Detects ~60 kDa. Band at 40 kDa is isoform 2.
- Réactivité croisée
- Humain, Souris
- Purification
- Peptide Affinity Purified
- Immunogène
- Synthetic peptide from the C-terminal of Human SQSTM1 (aa. 335-345)
- Isotype
- IgG
- Top Product
- Discover our top product SQSTM1 Anticorps primaire
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- Indications d'application
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- WB (1:1000)
- optimal dilutions for assays should be determined by the user.
- Commentaires
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A 1:1000 dilution of ABIN5066110 was sufficient for detection of SQSTM1 in 15 μg of Human HeLa Cell Lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Conjugated antibodies should be stored at 4°C
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- Antigène
- SQSTM1 (Sequestosome 1 (SQSTM1))
- Autre désignation
- SQSTM1 (SQSTM1 Produits)
- Synonymes
- anticorps SQSTM1, anticorps sqstm1, anticorps MGC79491, anticorps A170, anticorps OSIL, anticorps PDB3, anticorps ZIP3, anticorps p60, anticorps p62, anticorps p62B, anticorps OSF-6, anticorps Osi, anticorps STAP, anticorps ZIP, anticorps sb:cb621, anticorps zgc:85784, anticorps sequestosome 1, anticorps sequestosome 1 L homeolog, anticorps SQSTM1, anticorps sqstm1, anticorps Sqstm1, anticorps sqstm1.L
- Sujet
- SQSTM1 or Sequestome 1 (p62) is a ubiquitin binding protein that interacts with ubiqutin, providing a scaffold for several signaling proteins and triggering degradation of proteins throught the proteasome or lysossome. This gene regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Mutations in this gene result in sporadic and familial Paget disease of bone. SQSTM1 also binds autophagosomal membrane protein LC3/ATG8.
- ID gène
- 8878
- NCBI Accession
- NP_001135770
- UniProt
- Q13501
- Pathways
- Signalisation NF-kappaB, Neurotrophin Signaling Pathway, Autophagy
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