SCNN1B anticorps (AA 617-638) (HRP)

N° du produit ABIN5066888

Détail du produit anti-SCNN1B anticorps (HRP)

Antigène: SCNN1B (Sodium Channel, Nonvoltage-Gated 1, beta (SCNN1B))

Épitope: AA 617-638

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SCNN1B est conjugé à/à la HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: Detects ~87 kDa.

Réactivité croisée: Souris

Purification: Protein G Purified

Immunogène: Synthetic peptide from the C-terminal of Rat ENaC beta (aa. 617-638)

Clone: 7B8

Isotype: IgG1

Information d'application

Indications d'application:

• WB (1:1000)
• IHC (1:150)
• optimal dilutions for assays should be determined by the user.

Commentaires:

A 1:1000 dilution of ABIN5066888 was sufficient for detection of ENaC beta in 15 μg of Mouse whole kidney lysate by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Conjugated antibodies should be stored at 4°C

Détails sur SCNN1B

Antigène: SCNN1B (Sodium Channel, Nonvoltage-Gated 1, beta (SCNN1B))

Autre désignation: ENaC beta (SCNN1B Produits)

Synonymes: anticorps BESC1, anticorps ENaCb, anticorps ENaCbeta, anticorps SCNEB, anticorps RNENACB, anticorps besc1, anticorps betaxENaC, anticorps enacb, anticorps enacbeta, anticorps scnn1b, anticorps beta-ENaC, anticorps scneb, anticorps SCNN1B, anticorps BETA-ENAC, anticorps sodium channel epithelial 1 beta subunit, anticorps sodium channel, non voltage gated 1 beta subunit L homeolog, anticorps sodium channel, non voltage gated 1 beta subunit, anticorps sodium channel, nonvoltage-gated 1 beta, anticorps sodium channel, non voltage gated 1 beta subunit S homeolog, anticorps SCNN1B, anticorps Scnn1b, anticorps scnn1b.L, anticorps scnn1b, anticorps scnn1b.S

Sujet: The Epithelial Sodium Channel (ENaC) is a membrane ion channel permeable to Na+ ions. It is located in the apical plasma membrane of epithelia in the kidneys, lung, colon, and other tissues where it plays a role in trans epithelial Na+-ion transport (1). Specifically Na+ transport via ENaC occurs across many epithelial surfaces, and plays a key role in regulating salt and water absorption (2). ENaCs are composed of three structurally related subunits that form a tetrameric channel, alpha, beta, and gamma. The expression of its alpha and beta subunits is enhanced as keratinocytes differentiate (3, 4). The beta and gamma-ENaC subunits are essential for edema fluid to exert its maximal effect on net fluid absorption by distal lung epithelia(5). And it has been concluded that the subunits are differentially expressed in the retina of mice with ocular hypertension, therefore the up-regulation of alpha-ENaC proteins could serve as a protection mechanism against elevated intraocular pressure (6).

ID gène: 24767

NCBI Accession: NP_036780

UniProt: P37090