PD-1 anticorps (AA 21-167)

N° du produit ABIN532977

Détail du produit anti-PD-1 anticorps

Antigène: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Épitope: AA 21-167

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PD-1 est non-conjugé

Application: Flow Cytometry (FACS), Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Fonction: Mouse monoclonal antibody raised against partial recombinant PDCD1.

Réactivité croisée: Humain

Immunogène: Recombinant protein corresponding to amino acids 21-167 of human PDCD1.

Clone: 4F12

Isotype: IgG2b

Information d'application

Indications d'application: Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In PBS, pH 7.4 (10 % glycerol, 0.02 % sodium azide).

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.

Références pour anticorps anti-PD-1 (ABIN532977)

Latchman, Wood, Chernova, Chaudhary, Borde, Chernova, Iwai, Long, Brown, Nunes, Greenfield, Bourque, Boussiotis, Carter, Carreno, Malenkovich, Nishimura, Okazaki, Honjo, Sharpe, Freeman: "PD-L2 is a second ligand for PD-1 and inhibits T cell activation." dans: Nature immunology, Vol. 2, Issue 3, pp. 261-8, (2001) (PubMed).

Nishimura, Honjo: "PD-1: an inhibitory immunoreceptor involved in peripheral tolerance." dans: Trends in immunology, Vol. 22, Issue 5, pp. 265-8, (2001) (PubMed).

Okazaki, Maeda, Nishimura, Kurosaki, Honjo: "PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 24, pp. 13866-71, (2001) (PubMed).

Détails sur PD-1

Antigène: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Autre désignation: CD279 / PD1 (PDCD1 Produits)

Synonymes: anticorps CD279, anticorps PD-1, anticorps PD1, anticorps SLEB2, anticorps hPD-1, anticorps hPD-l, anticorps Ly101, anticorps Pdc1, anticorps programmed cell death 1, anticorps PDCD1, anticorps Pdcd1

ID gène: 5133

Pathways: Cancer Immune Checkpoints