IRS1 anticorps (pSer307)

N° du produit ABIN538222

Détail du produit anti-IRS1 anticorps

Antigène: IRS1 (Insulin Receptor Substrate 1 (IRS1))

Épitope: pSer307

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IRS1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Fonction: Rabbit polyclonal antibody raised against synthetic phosphopeptide of IRS1.

Specificité: Reactivity occurs against human IRS1 pS307 protein and This antibody is specific to the phosphorylated form of the protein. Reactivity with non-phosphorylated human IRS1 is minimal by ELISA.

Réactivité croisée: Poulet, Boeuf (Vache), Chien, Humain, Singe, Souris, Porc, Rat

Attributs du produit: Antibody Reactive Against Synthetic Peptide.

Immunogène: Synthetic phosphopeptide corresponding to residues surrounding S307 of human IRS1.

Information d'application

Indications d'application: ELISA (1:2000-1:10000)
Western Blot (1:250-1:1500)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 20 mM KH₂PO₄, 150 mM NaCl, pH 7.2 (0.01 % sodium azide)

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.

Références pour anticorps anti-IRS1 (ABIN538222)

Danielsson, Ost, Nystrom, Strålfors: "Attenuation of insulin-stimulated insulin receptor substrate-1 serine 307 phosphorylation in insulin resistance of type 2 diabetes." dans: The Journal of biological chemistry, Vol. 280, Issue 41, pp. 34389-92, (2005) (PubMed).

Andreozzi, DAlessandris, Federici, Laratta, Del Guerra, Del Prato, Marchetti, Lauro, Perticone, Sesti et al.: "Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin ..." dans: Endocrinology, Vol. 145, Issue 6, pp. 2845-57, (2004) (PubMed).

Jiang, Dallas-Yang, Liu, Moller, Zhang et al.: "Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance ..." dans: The Journal of biological chemistry, Vol. 278, Issue 1, pp. 180-6, (2002) (PubMed).

Détails sur IRS1

Antigène: IRS1 (Insulin Receptor Substrate 1 (IRS1))

Autre désignation: IRS1 (IRS1 Produits)

Synonymes: anticorps HIRS-1, anticorps G972R, anticorps IRS-1, anticorps IRS1IRM, anticorps irs1, anticorps irsu, anticorps IRS1, anticorps irs-1, anticorps irs1-a, anticorps insulin receptor substrate 1, anticorps insulin receptor substrate 2, anticorps insulin receptor substrate 1 S homeolog, anticorps IRS1, anticorps Irs1, anticorps irs2, anticorps irs1.S

ID gène: 3667

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Negative Regulation of Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process