DIO2 anticorps (Middle Region)

N° du produit ABIN5514705

Détail du produit anti-DIO2 anticorps

Antigène: DIO2 (Deiodinase, Iodothyronine, Type II (DIO2))

Épitope: Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DIO2 est non-conjugé

Application: Western Blotting (WB)

Séquence: ILLKHVVLLL SRSKSTRGEW RRMLTSEGLR CVWKSFLLDA YKQVKLGEDA

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human DIO2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 23 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur DIO2

Antigène: DIO2 (Deiodinase, Iodothyronine, Type II (DIO2))

Autre désignation: DIO2 (DIO2 Produits)

Synonymes: anticorps 5DII, anticorps D2, anticorps DIOII, anticorps SelY, anticorps TXDI2, anticorps AI324267, anticorps Deio2, anticorps cb684, anticorps DIO2, anticorps dio2-A, anticorps 5dii, anticorps sely, anticorps txdi2, anticorps iodothyronine deiodinase 2, anticorps deiodinase, iodothyronine, type II, anticorps deiodinase, iodothyronine, type 2 L homeolog, anticorps deiodinase, iodothyronine, type 2, anticorps type II iodothyronine deiodinase, anticorps DIO2, anticorps Dio2, anticorps dio2, anticorps dio2.L, anticorps LOC100861220

Sujet: The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alias Symbols: D2, 5DII, SelY, DIOII, TXDI2,

Protein Size: 273

ID gène: 1734

NCBI Accession: NM_000793, NP_000784

UniProt: Q92813

Pathways: Hormone Transport, Hormone Activity