OAZ1 anticorps (Middle Region)
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- Antigène Voir toutes OAZ1 Anticorps
- OAZ1 (Ornithine Decarboxylase Antizyme 1 (OAZ1))
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Épitope
- Middle Region
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Reactivité
- Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp OAZ1 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- PHPPLKIPGG RGNSQRDHSL SASILYSDER LNVTEEPTSN DKTRVLSIQS
- Purification
- Affinity purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of rat OAZ1
- Top Product
- Discover our top product OAZ1 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 16 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- OAZ1 (Ornithine Decarboxylase Antizyme 1 (OAZ1))
- Autre désignation
- OAZ1 (OAZ1 Produits)
- Synonymes
- anticorps AZI, anticorps OAZ, anticorps AZ-1, anticorps AZ1, anticorps Antizyme, anticorps ODC-Az, anticorps Oaz, anticorps ODCAC, anticorps oaz, anticorps AZS, anticorps oaz1, anticorps ornithine decarboxylase antizyme 1, anticorps ornithine decarboxylase antizyme 1 S homeolog, anticorps ornithine decarboxylase antizyme 1a, anticorps OAZ1, anticorps Oaz1, anticorps oaz1.S, anticorps oaz1a
- Sujet
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The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis, thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene.
Alias Symbols: AZ1, Oaz, AZ-1, ODC-Az, Antizyme,
Protein Size: 227 - ID gène
- 18245
- NCBI Accession
- NM_008753, NP_032779
- UniProt
- P54369
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