SAFB anticorps (N-Term)

N° du produit ABIN5515129

Détail du produit anti-SAFB anticorps

Antigène: SAFB (Scaffold Attachment Factor B (SAFB))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SAFB est non-conjugé

Application: Western Blotting (WB)

Séquence: MAETLSGLGD SGAAGAAALS SASSETGTRR LSDLRVIDLR AELRKRNVDS

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 93%, Rat: 100%

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human SAFB

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur SAFB

Antigène: SAFB (Scaffold Attachment Factor B (SAFB))

Autre désignation: SAFB (SAFB Produits)

Synonymes: anticorps HAP, anticorps HET, anticorps SAF-B1, anticorps SAFB1, anticorps 3110021E02Rik, anticorps 5330423C17Rik, anticorps AU018122, anticorps D18386, anticorps E130307D12, anticorps zgc:55387, anticorps wu:fb40a03, anticorps wu:fd42g06, anticorps SAFB2, anticorps SAFB, anticorps scaffold attachment factor B, anticorps scaffold attachment factor B S homeolog, anticorps SAFB-like transcription modulator, anticorps Scaffold attachment factor B, anticorps SAFB, anticorps Safb, anticorps safb, anticorps safb.S, anticorps LOC5570070, anticorps CpipJ_CPIJ017179, anticorps Bm1_49330, anticorps LOAG_00080

Sujet: This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements(S/MAR DNA). This protein is thought to be involved in attachingthe base of chromatin loops to the nuclear matrix but there isconflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factorsare a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serveas a molecular base to assemble a 'transcriptosome complex' in thevicinity of actively transcribed genes. It is involved in theregulation of heat shock protein 27 transcription, can act as anestrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcriptvariants encoding different isoforms have been found for this gene.

Alias Symbols: HAP, HET, SAF-B, SAFB1, SAB-B1, SAF-B1

Protein Interaction Partner: SUMO3, STAU1, UBC, LGR4, SUMO1, EED, rev, TP63, IL7R, CSNK2A1, MAP1LC3A, TP53BP1, TRMT112, TMOD2, RBMX, NCSTN, ACIN1, SMU1, U2AF2, CPSF6, GCN1L1, UTP14A, USP39, SAP18, VTN, U2AF1, TPBG, SURF4, SON, SRSF7, PRKAR1A, ABCC1, LAMP2, SEPT7, AK2, ACAT1, ZC3H18,

Protein Size: 848

ID gène: 6294

NCBI Accession: NM_002967, NP_002958

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway