DIO3 anticorps (Middle Region)
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- Antigène Voir toutes DIO3 Anticorps
- DIO3 (Deiodinase, Iodothyronine, Type III (DIO3))
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Épitope
- Middle Region
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp DIO3 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- EVELNSEGEE VPPDDPPICV SDDNRLCTLA SLKAVWHGQK LDFFKQAHEG
- Purification
- Affinity purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human DIO3
- Top Product
- Discover our top product DIO3 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- DIO3 (Deiodinase, Iodothyronine, Type III (DIO3))
- Autre désignation
- DIO3 (DIO3 Produits)
- Synonymes
- anticorps 5DIII, anticorps DIOIII, anticorps txdi3, anticorps dioiii, anticorps XL-15, anticorps itdi3, anticorps D3, anticorps TXDI3, anticorps iodothyronine deiodinase 3, anticorps deiodinase, iodothyronine, type 3, anticorps deiodinase, iodothyronine, type III, anticorps deiodinase, iodothyronine type III, anticorps deiodinase, iodothyronine, type 3 L homeolog, anticorps DIO3, anticorps dio3, anticorps Dio3, anticorps dio3.L
- Sujet
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The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.
Alias Symbols: D3, 5DIII, TXDI3, DIOIII,
Protein Size: 278 - ID gène
- 1735
- NCBI Accession
- NM_001362, NP_001353
- UniProt
- P55073
- Pathways
- Hormone Activity
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