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DIO3 anticorps (Middle Region)

DIO3 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN5515229
  • Antigène Voir toutes DIO3 Anticorps
    DIO3 (Deiodinase, Iodothyronine, Type III (DIO3))
    Épitope
    • 10
    • 7
    • 7
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivité
    • 39
    • 25
    • 18
    Humain
    Hôte
    • 49
    • 1
    Lapin
    Clonalité
    • 49
    • 1
    Polyclonal
    Conjugué
    • 19
    • 7
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp DIO3 est non-conjugé
    Application
    • 40
    • 25
    • 15
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    EVELNSEGEE VPPDDPPICV SDDNRLCTLA SLKAVWHGQK LDFFKQAHEG
    Purification
    Affinity purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the middle region of human DIO3
    Top Product
    Discover our top product DIO3 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    DIO3 (Deiodinase, Iodothyronine, Type III (DIO3))
    Autre désignation
    DIO3 (DIO3 Produits)
    Synonymes
    anticorps 5DIII, anticorps DIOIII, anticorps txdi3, anticorps dioiii, anticorps XL-15, anticorps itdi3, anticorps D3, anticorps TXDI3, anticorps iodothyronine deiodinase 3, anticorps deiodinase, iodothyronine, type 3, anticorps deiodinase, iodothyronine, type III, anticorps deiodinase, iodothyronine type III, anticorps deiodinase, iodothyronine, type 3 L homeolog, anticorps DIO3, anticorps dio3, anticorps Dio3, anticorps dio3.L
    Sujet
    The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.

    Alias Symbols: D3, 5DIII, TXDI3, DIOIII,

    Protein Size: 278
    ID gène
    1735
    NCBI Accession
    NM_001362, NP_001353
    UniProt
    P55073
    Pathways
    Hormone Activity
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