APOBEC3A anticorps (Middle Region)

N° du produit ABIN5515787

Détail du produit anti-APOBEC3A anticorps

Antigène: APOBEC3A (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3A (APOBEC3A))

Épitope: Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp APOBEC3A est non-conjugé

Application: Western Blotting (WB)

Séquence: PASGPRHLMD PHIFTSNFNN GIGRHKTYLC YEVERLDNGT SVKMDQHRGF

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human APOBEC3A

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur APOBEC3A

Antigène: APOBEC3A (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3A (APOBEC3A))

Autre désignation: APOBEC3A (APOBEC3A Produits)

Synonymes: anticorps A3A, anticorps ARP3, anticorps PHRBN, anticorps bK150C2.1, anticorps APOBEC3A, anticorps APOBEC3Z1, anticorps apolipoprotein B mRNA editing enzyme catalytic subunit 3A, anticorps apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A, anticorps apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3Z1, anticorps similar to ARP10 protein, anticorps APOBEC3A, anticorps APOBEC3Z1

Sujet: This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. The protein encoded by this gene is the same as that encoded by APOBEC3A, however, this gene is a hybrid gene that results from the deletion of approximately 29.5 kb of sequence between the APOBEC3A gene and the adjacent gene APOBEC3B. The breakpoints of the deletion are within the two genes, so the deletion hybrid is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B.

Protein Size: 199

ID gène: 100913187

NCBI Accession: NM_001193289, NP_001180218

UniProt: P31941