PRKAR1A anticorps (AA 2-81)
-
- Antigène Voir toutes PRKAR1A Anticorps
- PRKAR1A (Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A))
-
Épitope
- AA 2-81
-
Reactivité
- Humain, Rat
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp PRKAR1A est non-conjugé
-
Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Fonction
- Rabbit IgG polyclonal antibody for cAMP-dependent protein kinase type I-alpha regulatory subunit(PRKAR1A) detection. Tested with WB, IHC-P in Human,Rat.
- Réactivité croisée (Details)
- No cross reactivity with other proteins.
- Attributs du produit
-
Rabbit IgG polyclonal antibody for cAMP-dependent protein kinase type I-alpha regulatory subunit(PRKAR1A) detection. Tested with WB, IHC-P in Human,Rat.
Gene Name: protein kinase cAMP-dependent type I regulatory subunit alpha
Protein Name: cAMP-dependent protein kinase type I-alpha regulatory subunit - Purification
- Immunogen affinity purified.
- Immunogène
- E.coli-derived human PRKAR1A recombinant protein (Position: E2-E81). Human PRKAR1A shares 89.9% and 92.4% amino acid (aa) sequence identity with mouse and rat PRKAR1A, respectively.
- Isotype
- IgG
- Top Product
- Discover our top product PRKAR1A Anticorps primaire
-
-
- Indications d'application
-
WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users. - Commentaires
-
Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Concentration
- 500 μg/mL
- Buffer
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
-
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
-
- Antigène
- PRKAR1A (Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A))
- Autre désignation
- PRKAR1A (PRKAR1A Produits)
- Synonymes
- anticorps ACRDYS1, anticorps ADOHR, anticorps CAR, anticorps CNC, anticorps CNC1, anticorps PKR1, anticorps PPNAD1, anticorps PRKAR1, anticorps TSE1, anticorps 1300018C22Rik, anticorps RIalpha, anticorps Tse-1, anticorps Tse1, anticorps RIIA, anticorps prkar1a, anticorps zgc:92515, anticorps im:7047729, anticorps cnc1, anticorps pkr1, anticorps ppnad1, anticorps prkar1, anticorps tse1, anticorps protein kinase cAMP-dependent type I regulatory subunit alpha, anticorps protein kinase, cAMP dependent regulatory, type I, alpha, anticorps protein kinase cAMP-dependent type 1 regulatory subunit alpha, anticorps protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a, anticorps cAMP-dependent protein kinase type I-alpha regulatory subunit pseudogene, anticorps protein kinase cAMP-dependent type I regulatory subunit alpha S homeolog, anticorps PRKAR1A, anticorps Prkar1a, anticorps prkar1aa, anticorps LOC707275, anticorps prkar1a.S
- Sujet
-
CAMP-dependent protein kinase type I-alpha regulatory subunit is an enzyme that in humans is encoded by the PRKAR1A gene. This protein encoded by this gene was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed.
Synonyms: ACRDYS1 | ADOHR | CAR | CNC 1 | CNC | CNC1 | PKA RIA | PKR 1 | PKR1 | PPNAD 1 | PPNAD1 | PRKAR 1 | PRKAR1 | PRKAR1A | TSE 1 | TSE1 | P10644 - ID gène
- 5573
- UniProt
- P10644
- Pathways
- Signalisation Hedgehog, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma
-