CYP2D6 anticorps (C-Term)

N° du produit ABIN5518823

Détail du produit anti-CYP2D6 anticorps

Antigène: CYP2D6 (Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6))

Épitope: AA 315-347, C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CYP2D6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit IgG polyclonal antibody for Cytochrome P450 2D6(CYP2D6) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Séquence: AWGLLLMILH PDVQRRVQQE IDDVIGQVRR PEM

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Cytochrome P450 2D6(CYP2D6) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: cytochrome P450, family 2, subfamily D, polypeptide 6
Protein Name: Cytochrome P450 2D6

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human Cytochrome P450 2D6 (315-347aa AWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEM).

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Mouse, Rat, Predicted Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Détails sur CYP2D6

Antigène: CYP2D6 (Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6))

Autre désignation: CYP2D6 (CYP2D6 Produits)

Synonymes: anticorps CPD6, anticorps CYP2D, anticorps CYP2D7AP, anticorps CYP2D7BP, anticorps CYP2D7P2, anticorps CYP2D8P2, anticorps CYP2DL1, anticorps CYPIID6, anticorps P450-DB1, anticorps P450C2D, anticorps P450DB1, anticorps CYP2D42, anticorps MGC64445, anticorps cyp2d2, anticorps cyp2d6-a, anticorps CYP2D6, anticorps cytochrome P450 family 2 subfamily D member 6, anticorps cytochrome P450, family 2, subfamily D, polypeptide 6, anticorps cytochrome 2D6, anticorps cytochrome P450 family 2 subfamily D member 6 S homeolog, anticorps cytochrome P450 2D6, anticorps cytochrome P450 2D6-like, anticorps CYP2D6, anticorps cyp2d6-b, anticorps cyp2d6.S, anticorps cyp2d6, anticorps LOC100988273

Sujet: Cytochrome P450 2D6 (CYP2D6) is one of the most important enzymes involved in the metabolism of xenobiotics in the body. It is a member of Cytochrome P450, family 2, subfamily D, polypeptide 6. This gene is mapped to chromosome 22q13.1. It has got 497 amino acid proteins which shares 73 % sequence identity with the rat protein. CYP2D6 is highly expressed in human liver and it is the major isozyme involved in the formation of N-hydroxyprocainamide, a metabolite potentially involved in the drug-induced lupus syndrome observed with procainamide.

Synonyms: Cytochrome P450 2D6 | 1.14.14.1 | CYPIID6 | Cytochrome P450-DB1 | Debrisoquine 4-hydroxylase | CYP2D6 | CYP2DL1 | P10635

ID gène: 1565

UniProt: P10635