DERL1 anticorps (C-Term)
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- Antigène Voir toutes DERL1 Anticorps
- DERL1 (Der1-Like Domain Family, Member 1 (DERL1))
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Épitope
- AA 224-251, C-Term
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp DERL1 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
- Purification
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogène
- This DERL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 224-251 amino acids from the C-terminal region of human DERL1.
- Isotype
- Ig Fraction
- Top Product
- Discover our top product DERL1 Anticorps primaire
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- Indications d'application
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For WB starting dilution is: 1:2000
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50 - Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Supplied in PBS with 0.09 % (W/V) sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Antigène
- DERL1 (Der1-Like Domain Family, Member 1 (DERL1))
- Autre désignation
- DERL1 (DERL1 Produits)
- Synonymes
- anticorps CG10908, anticorps Dmel\\CG10908, anticorps DDBDRAFT_0188135, anticorps DDBDRAFT_0266772, anticorps DDB_0188135, anticorps DDB_0266772, anticorps MGC84200, anticorps wu:fb09d07, anticorps wu:fb94d05, anticorps wu:fj92g12, anticorps zgc:55637, anticorps 1110021N07Rik, anticorps AI195141, anticorps AW551338, anticorps Derlin-1, anticorps derlin-1, anticorps DER-1, anticorps DER1, anticorps RGD1311835, anticorps DERLIN-1, anticorps F17A13.150, anticorps F17A13_150, anticorps Derlin-1, anticorps derlin-1, anticorps derlin-1.1, anticorps hypothetical protein, anticorps Der1-like domain family, member 1, anticorps derlin 1, anticorps derlin 1 L homeolog, anticorps DERLIN-1, anticorps Der-1, anticorps EDI_023440, anticorps PTRG_01331, anticorps derl1, anticorps DERL1, anticorps derl1.L, anticorps Derl1, anticorps DER1
- Sujet
- Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. DERL1 may act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. It may mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.
- Poids moléculaire
- 29 kDa
- ID gène
- 79139
- UniProt
- Q9BUN8
- Pathways
- ER-Nucleus Signaling
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