EGLN3 anticorps (C-Term)

N° du produit ABIN5534232

Détail du produit anti-EGLN3 anticorps

Antigène: EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))

Épitope: AA 203-231, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EGLN3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This EGLN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 203-231 amino acids from the C-terminal region of human EGLN3.

Isotype: Ig Fraction

Information d'application

Indications d'application: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur EGLN3

Antigène: EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))

Autre désignation: EGLN3 (EGLN3 Produits)

Synonymes: anticorps zgc:77019, anticorps wu:fj78a08, anticorps EGLN3, anticorps phd3, anticorps PHD-3, anticorps PHD3, anticorps SM-20, anticorps 2610021G09Rik, anticorps AI505553, anticorps AI648162, anticorps Hif-p4h-3, anticorps Phd3, anticorps HIFP4H3, anticorps HIFPH3, anticorps egl-9 family hypoxia-inducible factor 3, anticorps egl-9 family hypoxia inducible factor 3, anticorps egl-9 family hypoxia-inducible factor 3 L homeolog, anticorps egln3, anticorps EGLN3, anticorps egln3.L, anticorps Egln3

Sujet: EGLN3 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. May play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. Promotes cell death through a caspase-dependent mechanism (By similarity).

Poids moléculaire: 27 kDa

ID gène: 112399

UniProt: Q9H6Z9

Pathways: Positive Regulation of Endopeptidase Activity