PHD1 anticorps (AA 194-221)

N° du produit ABIN5534259

Détail du produit anti-PHD1 anticorps

Antigène: PHD1 (EGLN2) (Egl-9 Family Hypoxia Inducible Factor 2 (EGLN2))

Épitope: AA 194-221

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PHD1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This EGLN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 194-221 amino acids from the Central region of human EGLN2.

Isotype: Ig Fraction

Information d'application

Indications d'application: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

For FACS starting dilution is: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur PHD1

Antigène: PHD1 (EGLN2) (Egl-9 Family Hypoxia Inducible Factor 2 (EGLN2))

Autre désignation: EGLN2 (EGLN2 Produits)

Synonymes: anticorps egln2, anticorps phd2, anticorps PHD1, anticorps 0610011A13Rik, anticorps C85656, anticorps Hif-p4h-1, anticorps Ier4, anticorps Phd1, anticorps SM-20, anticorps HIF-PH1, anticorps HPH-1, anticorps HPH-3, anticorps PHD-1, anticorps EIT6, anticorps HIFPH1, anticorps egl-9 family hypoxia-inducible factor 1, anticorps egl-9 family hypoxia inducible factor 2, anticorps Egl nine homolog 2, anticorps egl-9 family hypoxia-inducible factor 2 L homeolog, anticorps egl-9 family hypoxia-inducible factor 2, anticorps egln1, anticorps EGLN2, anticorps egln2, anticorps egln2.L, anticorps Egln2

Sujet: EGLN2 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-402' and 'Pro-564', and HIF-2 alpha. It functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. It may play a role in cell growth regulation.

Poids moléculaire: 44 kDa

ID gène: 112398

UniProt: Q96KS0

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Cell RedoxHomeostasis