RNF126 anticorps (AA 84-115)

N° du produit ABIN5535240

Détail du produit anti-RNF126 anticorps

Antigène: RNF126 (Ring Finger Protein 126 (RNF126))

Épitope: AA 84-115

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RNF126 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This RNF126 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 84-115 amino acids from the Central region of human RNF126.

Isotype: Ig Fraction

Information d'application

Indications d'application: For WB starting dilution is: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur RNF126

Antigène: RNF126 (Ring Finger Protein 126 (RNF126))

Autre désignation: RNF126 (RNF126 Produits)

Synonymes: anticorps 2610010O19Rik, anticorps ring finger protein 126, anticorps RNF126, anticorps Rnf126

Sujet: E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates 'Lys- 48'- and 'Lys-63'-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome (PubMed:< a href="http://www.uniprot.org/citations/24981174" target="_blank">24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:< a href="http://www.uniprot.org/citations/24275455" target="_blank">24275455). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:< a href="http://www.uniprot.org/citations/23026136" target="_blank">23026136). May monoubiquitinate AICDA (PubMed:< a href="http://www.uniprot.org/citations/23277564" target="_blank">23277564).

Poids moléculaire: 36 kDa

ID gène: 55658

UniProt: Q9BV68