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AF9 anticorps (AA 407-438)

MLLT3 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN5537119
  • Antigène Voir toutes AF9 (MLLT3) Anticorps
    AF9 (MLLT3) (Protein AF-9 (MLLT3))
    Épitope
    • 11
    • 8
    • 7
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 407-438
    Reactivité
    • 47
    • 9
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 46
    • 1
    Lapin
    Clonalité
    • 46
    • 1
    Polyclonal
    Conjugué
    • 30
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp AF9 est non-conjugé
    Application
    • 37
    • 20
    • 17
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
    Immunogène
    This AF9 (MLLT3) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 407-438 amino acids from the Central region of human AF9 (MLLT3).
    Isotype
    Ig Fraction
    Top Product
    Discover our top product MLLT3 Anticorps primaire
  • Indications d'application
    For WB starting dilution is: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    2 mg/mL
    Buffer
    Supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Antigène
    AF9 (MLLT3) (Protein AF-9 (MLLT3))
    Autre désignation
    AF9 (MLLT3 Produits)
    Synonymes
    anticorps fc39c11, anticorps wu:fc39c11, anticorps zgc:110210, anticorps AF9, anticorps YEATS3, anticorps 2210011H10Rik, anticorps 2610012I03Rik, anticorps 3830408D16Rik, anticorps Af9, anticorps D4Ertd321e, anticorps Af-9, anticorps MLLT3, super elongation complex subunit, anticorps myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3, anticorps mllt3, anticorps MLLT3, anticorps Mllt3
    Sujet
    The human AF9 gene is one of the most common fusion partner genes with the ALL1 gene at 11q23 (also called MLL), resulting in the t(9,11)(p22,q23). The AF9 gene is more than 100 kb, and 2 patient breakpoint cluster regions (BCRs) have been identified, BCR1 is within intron 4, previously called site A, whereas BCR2 or site B spans introns 7 and 8. Several different structural elements have been identified in AF9, including a colocalizing in vivo DNA topo II cleavage site and an in vitro DNase I hypersensitive (DNase 1 HS) site in intron 7 in BCR2. Reversibility experiments demonstrated a religation of the topo II cleavage sites. In addition, 2 scaffold associated regions (SARs) are located centromeric to the topo II and DNase I HS cleavage sites and border breakpoint regions in 2 leukemic cells lines: SAR1 is located in intron 4, whereas SAR2 encompasses parts of exons 5-7. The patient breakpoint regions of AF9 share the same structural elements as the MLL BCR. A DNA breakage and repair model for nonhomologous recombination between MLL and its partner genes, particularly AF9, has been proposed.
    Poids moléculaire
    63 kDa
    ID gène
    4300
    UniProt
    P42568
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