TRIM72 anticorps (C-Term)

N° du produit ABIN5537808

Détail du produit anti-TRIM72 anticorps

Antigène: TRIM72 (Tripartite Motif Containing 72 (TRIM72))

Épitope: AA 299-327, C-Term

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRIM72 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This TRIM72 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 299-327 amino acids from the C-terminal region of human TRIM72.

Isotype: Ig Fraction

Information d'application

Indications d'application: For WB starting dilution is: 1:2000

For IHC-P starting dilution is: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.42 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur TRIM72

Antigène: TRIM72 (Tripartite Motif Containing 72 (TRIM72))

Autre désignation: TRIM72 (TRIM72 Produits)

Synonymes: anticorps Trim72, anticorps MG53, anticorps Mg53, anticorps BC067209, anticorps RGD1562778, anticorps tripartite motif containing 72, anticorps tripartite motif containing 72, E3 ubiquitin protein ligase L homeolog, anticorps tripartite motif-containing 72, anticorps TRIM72, anticorps trim72.L, anticorps Trim72

Sujet: TRIM72 is a muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).

Poids moléculaire: 53 kDa

ID gène: 493829

UniProt: Q6ZMU5