CLP1 anticorps (C-Term)

N° du produit ABIN5538448

Détail du produit anti-CLP1 anticorps

Antigène: CLP1 (Cleavage and Polyadenylation Factor I Subunit 1 (CLP1))

Épitope: AA 308-336, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CLP1 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This CLP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-336 amino acids from the C-terminal region of human CLP1.

Isotype: Ig Fraction

Information d'application

Indications d'application: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur CLP1

Antigène: CLP1 (Cleavage and Polyadenylation Factor I Subunit 1 (CLP1))

Autre désignation: CLP1 (CLP1 Produits)

Synonymes: anticorps Heab, anticorps RGD1307679, anticorps AI462438, anticorps ACDP1, anticorps CLP-1, anticorps CGP-39, anticorps GP-39, anticorps SPC-40, anticorps SPS-40, anticorps YKL-40, anticorps HEAB, anticorps hClp1, anticorps fa28a12, anticorps wu:fa28a12, anticorps clp1, anticorps cleavage and polyadenylation factor I subunit 1, anticorps CLP1, cleavage and polyadenylation factor I subunit, anticorps cyclin and CBS domain divalent metal cation transport mediator 1, anticorps chitinase 3-like 1 (cartilage glycoprotein-39), anticorps cleavage and polyadenylation factor I subunit 1 L homeolog, anticorps Clp1, anticorps CNNM1, anticorps CHI3L1, anticorps CLP1, anticorps clp1, anticorps clp1.L

Sujet: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing, this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.

Poids moléculaire: 48 kDa

ID gène: 10978

UniProt: Q92989

Pathways: Ribonucleoprotein Complex Subunit Organization