SGOL2 anticorps (AA 391-419)

N° du produit ABIN5538697

Détail du produit anti-SGOL2 anticorps

Antigène: SGOL2 (Shugoshin-Like 2 (SGOL2))

Épitope: AA 391-419

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SGOL2 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This SGOL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-419 amino acids from the Central region of human SGOL2.

Isotype: Ig Fraction

Information d'application

Indications d'application: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur SGOL2

Antigène: SGOL2 (Shugoshin-Like 2 (SGOL2))

Autre désignation: SGOL2 (SGOL2 Produits)

Synonymes: anticorps SGO2, anticorps TRIPIN, anticorps 1110007N04Rik, anticorps 4932411A20Rik, anticorps 5730576N04Rik, anticorps AU018846, anticorps AV008062, anticorps D1Ertd8e, anticorps Tripin, anticorps shugoshin 2, anticorps shugoshin 2A, anticorps SGO2, anticorps Sgo2a

Sujet: Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.

Poids moléculaire: 145 kDa

ID gène: 151246

UniProt: Q562F6