KDM5D anticorps (C-Term)

N° du produit ABIN5541915

Détail du produit anti-KDM5D anticorps

Antigène: KDM5D (Lysine (K)-Specific Demethylase 5D (KDM5D))

Épitope: AA 1248-1539, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KDM5D est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody detects Human JARID1D. Other species not tested.

Purification: Protein A Chromatography

Immunogène: Highly pure (> 95%) recombinant Human JARID1D (Leu1248-Leu1539) fused to a C-terminal His-tag (6x His) derived from E. coli (Cat.-No AR60001PU-N)

Isotype: IgG

Information d'application

Indications d'application: Western blot: 1-5 μg/mL.

Restrictions: For Research Use only

Stockage

Buffer: Purification: Protein A Chromatography

Stock: 4 °C,-20 °C

Stockage commentaire: Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur KDM5D

Antigène: KDM5D (Lysine (K)-Specific Demethylase 5D (KDM5D))

Autre désignation: jarid1d (KDM5D Produits)

Synonymes: anticorps JARID1D, anticorps Jarid1d, anticorps DKFZp468I1010, anticorps HY, anticorps HYA, anticorps SMCY, anticorps Smcy, anticorps lysine demethylase 5D, anticorps lysine (K)-specific demethylase 5D, anticorps lysine demethylase 5C, anticorps KDM5D, anticorps Kdm5d, anticorps KDM5C

Sujet: H-Y antigen is defined as a male histocompatibility antigen that causes rejection of male skin grafts by female recipients of the same inbred strain of rodents. Male-specific, or H-Y antigen(s), are also detected by cytotoxic T cells and antibodies. H-Y antigen appears to be an integral part of the membrane of most male cells. In addition, H-Y antibodies detect a soluble form of H-Y that is secreted by the testis. The gene (Smcy/SMCY) coding for H-Y antigen detected by T cells has been cloned. It is expressed ubiquitously in male mice and humans, and encodes an epitope that triggers a specific T-cell response in vitro. Additional epitopes coded for by different Y-chromosomal genes are probably required in vivo for the rejection of male grafts by female hosts. The molecular nature of H-Y antigen detected by antibodies on most male cells is not yet known. Testis-secreted, soluble H-Y antigen, however, was found to be identical to Müllerian-inhibiting substance (MIS). MIS cross-reacts with H-Y antibodies and identical findings were obtained for soluble H-Y antigen and MIS, i.e., secretion by testicular Sertoli and, to a lesser degree, ovarian cells, binding to a gonad-specific receptor, induction of gonadal sex reversal in vitro and, in cattle, in vivo. H-Y antisera also detect a molecule or molecules associated with the heterogametic sex in non-mammalian vertebrates. Molecular data on this antigen or antigens are not yet available.

Pathways: L'effet Warburg