PTPN1 anticorps (AA 40-246)

N° du produit ABIN5542666

Détail du produit anti-PTPN1 anticorps

Antigène: PTPN1 (Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1))

Épitope: AA 40-246

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PTPN1 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: purified

Immunogène: Purified recombinant fragment of human PTPN1 (AA: 40-246) expressed in E. coli.

Clone: 4F8F2

Isotype: IgG2b

Information d'application

Indications d'application: ELISA: 1:10000, WB: 1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Détails sur PTPN1

Antigène: PTPN1 (Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1))

Autre désignation: PTPN1 (PTPN1 Produits)

Synonymes: anticorps PTPN1, anticorps PTP1B, anticorps PTP-1B, anticorps PTP-HA2, anticorps Ptp, anticorps ptp1b, anticorps wu:fk54h03, anticorps CPTP1, anticorps protein tyrosine phosphatase, non-receptor type 1, anticorps protein tyrosine phosphatase, non-receptor type 1 L homeolog, anticorps PTPN1, anticorps Ptpn1, anticorps ptpn1, anticorps ptpn1.L

Sujet:

Description: The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene.

Aliases: PTP1B

Poids moléculaire: 50 kDa

ID gène: 5770

HGNC: 5770

Pathways: Signalisation TLR, Response to Growth Hormone Stimulus, ER-Nucleus Signaling, Platelet-derived growth Factor Receptor Signaling