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CREB1 anticorps (pSer133)

CREB1 Reactivité: Humain, Souris, Rat, Poisson zèbre (Danio rerio), Boeuf (Vache), Poulet, Mouton, Chien, Xenopus laevis, Non-Human Primate WB, IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN372604
  • Antigène Voir toutes CREB1 Anticorps
    CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))
    Épitope
    • 66
    • 29
    • 20
    • 17
    • 16
    • 16
    • 10
    • 8
    • 8
    • 8
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    • 1
    • 1
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    • 1
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    pSer133
    Reactivité
    • 291
    • 213
    • 179
    • 33
    • 23
    • 17
    • 16
    • 13
    • 11
    • 10
    • 9
    • 8
    • 7
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    • 1
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    • 1
    Humain, Souris, Rat, Poisson zèbre (Danio rerio), Boeuf (Vache), Poulet, Mouton, Chien, Xenopus laevis, Non-Human Primate
    Hôte
    • 264
    • 29
    • 1
    • 1
    Lapin
    Clonalité
    • 239
    • 56
    Polyclonal
    Conjugué
    • 148
    • 16
    • 14
    • 12
    • 12
    • 11
    • 11
    • 11
    • 11
    • 10
    • 10
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    Cet anticorp CREB1 est non-conjugé
    Application
    • 224
    • 100
    • 98
    • 74
    • 56
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    • 20
    • 17
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    • 6
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    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificité
    Specific for the ~45k CREB protein phosphorylated at Ser133. Immunolabeling is blocked by lambda-phosphatase treatment.
    Réactivité croisée (Details)
    Species reactivity (expected):Bovine, Canine, Chicken, Human, Mouse, Sheep, Xenopus, Zebrafish and non-Human Primates.
    Species reactivity (tested):Rat.
    Purification
    Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
    Immunogène
    Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser133 of rat CREB.
    Isotype
    IgG
    Top Product
    Discover our top product CREB1 Anticorps primaire
  • Indications d'application
    Western Blot: 1/1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
    Stockage commentaire
    Store the antibody undiluted (in aliquots) at-20 °C.
  • Antigène
    CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))
    Autre désignation
    CREB1 (CREB1 Produits)
    Synonymes
    anticorps creb, anticorps CREB1, anticorps Creb1, anticorps CREB, anticorps 2310001E10Rik, anticorps 3526402H21Rik, anticorps AV083133, anticorps Creb, anticorps Creb-1, anticorps creb1, anticorps zgc:55598, anticorps cAMP responsive element binding protein 1, anticorps cAMP responsive element binding protein, anticorps cAMP responsive element binding protein 1 S homeolog, anticorps cAMP responsive element binding protein 1a, anticorps CREB1, anticorps creb1, anticorps CREB, anticorps Creb1, anticorps creb1.S, anticorps creb1a
    Sujet
    It is well known that the control of gene expression involves activation of protein kinase cascades that regulate transcription factors within the nucleus (Karin and Hunter, 1995). The cyclic AMP response element binding protein (CREB) is one of the best characterized stimulus-induced transcription factors (Montminy, 1997). This transcription factor is a component of intracellular signaling events that regulate a wide range of biological functions, from spermatogenesis to circadian rhythms and memory (Shaywitz and Greenberg, 1999, Silva et al., 1998). A variety of protein kinases including protein kinase A (PKA), mitogen-activated protein kinases (MAPKs), and Ca2+/calmodulin-dependent protein kinases (CaMKs) phosphorylate CREB at serine 133 (Ser133), and phosphorylation of Ser133 are required for CREB-mediated transcription (Johannessen et al., 2004, Kornhauser et al., 2002).Synonyms: CREB-1, Cyclic AMP-responsive element-binding protein 1, cAMP-responsive element-binding protein 1
    ID gène
    81646
    NCBI Accession
    NP_112279
    UniProt
    P15337
    Pathways
    Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Regulation of Cell Size, Toll-Like Receptors Cascades, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Positive Regulation of fat Cell Differentiation
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