FANCC anticorps (AA 96-112)

N° du produit ABIN401268

Détail du produit anti-FANCC anticorps

Antigène: FANCC (Fanconi Anemia, Complementation Group C (FANCC))

Épitope: AA 96-112

Reactivité: Humain, Chimpanzé

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FANCC est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody is directed against human FANCC protein.

Réactivité croisée (Details): Species reactivity (expected):Chimpanzee (100 %).
Species reactivity (tested):Human.

Purification: Affinity Purified

Immunogène: Synthetic peptide corresponding to amino acids 96-112 of Human FANCC

Isotype: IgG

Information d'application

Indications d'application: ELISA: 1: 20,000 - 1: 80,000. Western blot: 1: 1,000 - 1: 3,000 (Expect a band approximately 63 kDa in size correspondingto FANCC in the appropriate human tissue).

Restrictions: For Research Use only

Stockage

Concentration: 1.45 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing. Should this product contain a precipitate we recommend microcentrifugation before use.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Détails sur FANCC

Antigène: FANCC (Fanconi Anemia, Complementation Group C (FANCC))

Autre désignation: FANCC (FANCC Produits)

Synonymes: anticorps zgc:154105, anticorps FANCC, anticorps fa3, anticorps fac, anticorps facc, anticorps FA3, anticorps FAC, anticorps FACC, anticorps BB116513, anticorps Facc, anticorps Fanconi anemia complementation group C, anticorps Fanconi anemia, complementation group C, anticorps Fanconi anemia complementation group C L homeolog, anticorps FANCC, anticorps fancc, anticorps fancc.L, anticorps Fancc

Sujet: FANCC (also called Protein FACC or Fanconi Anemia Group C protein) is involved in DNA repair, perhaps specifically with post-replication repair or a cell cycle checkpoint function. FANCC may also be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. FANCC belongs to the multi-subunit Fanconi Anemia (FA) complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. FANCC is mainly found within the nucleus although some protein is localized in the cytoplasm. This protein is ubiquitously expressed. Defects in FANCC are a cause of Fanconi anemia (FA). FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopaenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNAdamaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair.Synonyms: FAC, FACC, Fanconi anemia group C protein

ID gène: 2176

NCBI Accession: NP_000127

UniProt: Q00597

Pathways: Réparation de l'ADN