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SIGLEC8 anticorps (Internal Region)

SIGLEC8 Reactivité: Humain WB Hôte: Chèvre Polyclonal unconjugated
N° du produit ABIN375053
  • Antigène Voir toutes SIGLEC8 Anticorps
    SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))
    Épitope
    • 8
    • 7
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 44
    • 7
    • 2
    Humain
    Hôte
    • 33
    • 10
    • 1
    Chèvre
    Clonalité
    • 35
    • 9
    Polyclonal
    Conjugué
    • 24
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SIGLEC8 est non-conjugé
    Application
    • 33
    • 20
    • 19
    • 7
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Specificité
    This antibody reacts to SIGLEC8.
    Purification
    Affinity chromatography
    Immunogène
    Peptide with sequence C-SYKSQLNYKTKQ, from the internal region of the protein sequence
    Top Product
    Discover our top product SIGLEC8 Anticorps primaire
  • Indications d'application
    Peptide ELISA: 1/32000. Western Blot: 0.3 - 1 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0,5 mg/mL
    Buffer
    Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Yokoi, Choi, Hubbard, Lee, Canning, Lee, Ryu, von Gunten, Bickel, Hudson, Macglashan, Bochner: "Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement." dans: The Journal of allergy and clinical immunology, Vol. 121, Issue 2, pp. 499-505.e1, (2008) (PubMed).

  • Antigène
    SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))
    Autre désignation
    CD329 / SIGLEC8 (SIGLEC8 Produits)
    Synonymes
    anticorps SAF2, anticorps SIGLEC-8, anticorps SIGLEC8L, anticorps SIGLEC8, anticorps sialic acid binding Ig like lectin 8, anticorps sialic acid-binding Ig-like lectin 8, anticorps SIGLEC8, anticorps LOC506364
    Sujet
    SIGLEC8 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It preferentially binds to alpha2,3-linked sialic acid. and also binds to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC8 is expressed specifically on eosinophils. The protein contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The SIGLEC8 gene belongs to the immunoglobulin superfamily.Synonyms: CDw329, SAF2, Sialic acid-binding Ig-like lectin 8, Sialoadhesin family member 2, Siglec-8
    ID gène
    27181, 9606
    UniProt
    Q9NYZ4
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